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Ac4ManNDAz

Cat. No. 7553 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Photo-crosslinking probe for studying glycoproteins and glycolipids
化学名： 2-Deoxy-2-[[3-(3-methyl-3H-diazirin-3-yl)-1-oxopropyl]amino]-D-mannopyranose-1,3,4,6-tetraacetate
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Ac4ManNDAz

Ac4ManNDAz is a cell-permeable photo-crosslinking probe for studying glycoprotein or glycolipid interactions. The compound is an unnatural diazirine-containing monosaccharide building block, which acts as a photo-crosslinker. Once inside the cell, Ac4ManNDAz is metabolized and incorporated into cell surface glycoproteins as a photo-crosslinking sialic acid analog. Upon UV irradiation, the diazirine group is activated to a reactive carbene that covalently crosslinks to nearby molecules.

技术数据 for Ac4ManNDAz

分子量 457.44
公式 C19H27N3O10
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1015698-39-1
PubChem ID 122400676
InChI Key UZYLHDJBFVVKBM-GAMQSXCYSA-N
Smiles CC(OC[C@H]1OC([C@H]([C@H]([C@@H]1OC(C)=O)OC(C)=O)NC(CCC2(N=N2)C)=O)OC(C)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Ac4ManNDAz

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
ethanol 45.74 100
DMSO 45.74 100

制备储备液 for Ac4ManNDAz

以下数据基于产品分子量 457.44。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.19 mL 10.93 mL 21.86 mL
5 mM 0.44 mL 2.19 mL 4.37 mL
10 mM 0.22 mL 1.09 mL 2.19 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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参考文献 for Ac4ManNDAz

参考文献是支持产品生物活性的出版物。

Tanaka et al (2008) Photoactivatable crosslinking sugars for capturing glycoprotein interactions. J.Am.Chem.Soc. 130 3278 PMID: 18293988

Bond et al (2009) Photocrosslinking of glycoconjugates using metabolically incorporated diazirine-containing sugars. Nat.Protoc. 4 1044 PMID: 19536272

Bond et al (2011) Metabolism of diazirine-modified N-acetylmannosamine analogues to photo-cross-linking sialosides. Bioconjug.Chem. 22 1811 PMID: 21838313

Cervin et al (2018) GM1 ganglioside-independent intoxication by Cholera toxin. PLoS.Pathog. 14 e1006862 PMID: 29432456

If you know of a relevant reference for Ac4ManNDAz, please let us know.

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关键词: Ac4ManNDAz, Ac4ManNDAz supplier, cell-permeable, unnatural, diazirine, containing, monosaccharide, building, block, photoactivate, photoactivatable, cross-linker, cross-linking, sialic, acids, analog, glycoproteins, glycolipids, probes, probe, Post-translational, Modifications, Biochemicals, and, Molecular, Biology, Glycobiology, Probes, 7553, Tocris Bioscience

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