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AEG 40730 dihydrochloride

Cat. No. 5330 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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5330 has been discontinued.

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说明： IAP antagonist; induces apoptosis
化学名： 222,Trifluoro-N-[[(2S)-1-(N-methyl-L-analyl-L-threonyl)-2-pyrrolidinyl]methyl]-N-(2-phenylethyl)acetamide, diethyl ether with 2,4-hexadiyne-1.6-diol dihydrochloride
纯度： ≥97% (HPLC)
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生物活性 技术数据 说明书 参考文献

生物活性 for AEG 40730 dihydrochloride

AEG 40730 dihydrochloride is an IAP antagonist; binds to the BIR3 domain of cIAP1, cIAP2 and XIAP with nanomolar affinity. Reduces cIAP1, cIAP2 and XIAP protein levels in human breast cancer MDA-MB-231 cells. Induces apoptosis in combination with TNF, and potentiates TRAIL-mediated apoptosis in human colorectal carcinoma HCT 116 cells. Cell permeable.

技术数据 for AEG 40730 dihydrochloride

分子量 1120.06
公式 C52H68F6N8O8.2HCl
储存 Store at -20°C
纯度 ≥97% (HPLC)
CAS Number 1883545-50-3
PubChem ID 91826085
InChI Key CDGBXBVDDLOZGF-CLHBFWEXSA-N
Smiles O=C([C@H](C)NC)N[C@@H]([C@H](OCC#CC#CCO[C@H](C)[C@H](NC([C@H](C)NC)=O)C(N2[C@H](CN(CCC3=CC=CC=C3)C(C(F)(F)F)=O)CCC2)=O)C)C(N1[C@H](CN(C(C(F)(F)F)=O)CCC4=CC=CC=C4)CCC1)=O.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for AEG 40730 dihydrochloride

分析证书/产品说明书
化学品安全技术说明书

参考文献 for AEG 40730 dihydrochloride

参考文献是支持产品生物活性的出版物。

Beug et al (2014) Smac mimetics and innate immune stimuli synergize to promote tumor death. Nat.Biotechnol. 32 182 PMID: 24463573

Galbán et al (2009) Cytoprotective effects of IAPs revealed by a small molecule antagonist. Biochem.J. 417 765 PMID: 18851715

Bertrand et al (2008) cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination. Mol. Cell 30 689 PMID: 18570872

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关键词: AEG 40730 dihydrochloride, AEG 40730 dihydrochloride supplier, AEG40730, dihydrochloride, 934963583, 934963, 58, 3, IAP, inhibitors, inhibits, apoptosis, antagonists, cIAP1, cIAP2, XIAP, cellular, BIR3, Apoptosis, Inducers, 5330, Tocris Bioscience

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Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for AEG 40730 dihydrochloride

Apoptosis Signaling Pathway

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.