Aliskiren hemifumarate

Cat. No. 5491 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent renin inhibitor; antihypertensive

别名： SPP 100

化学名： (αS,γS,δS,ζS)-δ-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)benzeneoctanamide hemifumarate

纯度： ≥99% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Aliskiren hemifumarate

Aliskiren hemifumarate is a potent renin inhibitor (IC₅₀ = 0.6 and 80 nM for human and rat respectively). Exhibits selectivity for renin over a range of other aspartic proteinases (>5000 nM). Lowers blood pressure in a hypertensive rodent model. Orally active.

化合物库 for Aliskiren hemifumarate

Aliskiren hemifumarate is also offered as part of the Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Aliskiren hemifumarate

分子量	609.83
公式	C₃₀H₅₃N₃O6.1/2C₄H₄O₄
储存	Store at -20°C
纯度	≥99% (HPLC)
CAS Number	173334-58-2
PubChem ID	6918427
InChI Key	KLRSDBSKUSSCGU-KRQUFFFQSA-N
Smiles	COC1=C(OCCCOC)C=C(C[C@H]([C@@H](C)C)C[C@@H]([C@@H](O)C[C@@H]([C@@H](C)C)C(NCC(C)(C)C(N)=O)=O)N)C=C1.COC2=C(OCCCOC)C=C(C[C@H]([C@@H](C)C)C[C@@H]([C@@H](O)C[C@@H]([C@@H](C)C)C(NCC(C)(C)C(N)=O)=O)N)C=C2.O=C(/C=C/C(O)=O)O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Aliskiren hemifumarate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	60.98	100
	DMSO	60.98	100

制备储备液 for Aliskiren hemifumarate

以下数据基于产品分子量 609.83。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.64 mL	8.2 mL	16.4 mL
5 mM	0.33 mL	1.64 mL	3.28 mL
10 mM	0.16 mL	0.82 mL	1.64 mL
50 mM	0.03 mL	0.16 mL	0.33 mL

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产品说明书 for Aliskiren hemifumarate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Aliskiren hemifumarate

参考文献是支持产品生物活性的出版物。

Jensen et al (2) Aliskiren: the first renin inhibitor for clinical treatment. Nat.Rev.Drug Discov. 7 399 PMID: 18340340

Kaye and Krum (2007) Drug discovery for heart failure: a new era or the end of the pipeline? Nat.Rev.Drug Discov. 6 127 PMID: 17268484

If you know of a relevant reference for Aliskiren hemifumarate, please let us know.

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