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说明： Potent glucokinase activator; orally bioavailable
化学名： N-[6'-(2-Hydroxy-2-methylpropoxy)-4-[(5-methyl-3-pyridinyl)oxy][3,3'-bipyridin]-6-yl]-N'-methylurea
纯度： ≥98% (HPLC)
生物活性 for AM 2394
AM 2394 is a potent glucokinase activator (EC50 = 60 nM). Orally bioavailable. Reduces plasma glucose levels in an oral glucose tolerance test in ob/ob mice.
技术数据 for AM 2394
| 分子量 | 423.47 |
| 公式 | C22H25N5O4 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1442684-77-6 |
| PubChem ID | 71603585 |
| InChI Key | QUISANLDBDCMPD-UHFFFAOYSA-N |
| Smiles | O=C(NC)NC1=CC(OC2=CC(C)=CN=C2)=C(C3=CN=C(OCC(C)(C)O)C=C3)C=N1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for AM 2394
参考文献 for AM 2394
参考文献是支持产品生物活性的出版物。
Dransfield et al (2016) Novel series of potent glucokinase activators leading to the discovery of AM-2394. ACS Med.Chem.Lett. 7 714 PMID: 27437083
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关键词: AM 2394, AM 2394 supplier, AM2394, glucokinase, activators, activates, GKA, antidiabetic, potent, orally, bioavailable, Hexokinases, Enzyme, Substrates, /, Activators, 6034, Tocris Bioscience
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