Amyloid β-Peptide (1-42) (human)

Pricing Availability   Qty
说明: Predominant amyloid β-protein fragment
纯度: ≥95% (HPLC)
说明书
引用文献 (6)
评论 (1)
文献 (1)

生物活性 for Amyloid β-Peptide (1-42) (human)

Amyloid β-Peptide (1-42) (human) is a human form of the predominant amyloid β-peptide found in the brains of patients with Alzheimer's disease. Downregulates bcl-2 and increases the levels of bax. Neurotoxic.

Control Peptide also available.

技术数据 for Amyloid β-Peptide (1-42) (human)

分子量 4514.08
公式 C203H311N55O60S
序列 DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 107761-42-2
PubChem ID 16135558
InChI Key DZHSAHHDTRWUTF-SIQRNXPUSA-N
Smiles [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Amyloid β-Peptide (1-42) (human)

溶解性 Soluble to 1 mg/ml in 50mM Tris buffer

产品说明书 for Amyloid β-Peptide (1-42) (human)

分析证书/产品说明书
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参考文献 for Amyloid β-Peptide (1-42) (human)

参考文献是支持产品生物活性的出版物。

Glenner and Wong (1984) Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem.Biophys.Res.Commun. 120 885 PMID: 6375662

Paradis et al (1996) Amyloid beta peptide of Alzheimer's disease downregulates bcl-2 and upregulates bax expression in human neurons. J.Neurosci. 16 7533 PMID: 8922409

Van Nostrand et al (1996) Amyloid β-protein induces the cerebrovascular cellular pathology of Alzheimer's disease and related disorders. Ann.N.Y.Acad.Sci. 777 297 PMID: 8624102


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关键词: Amyloid beta-peptide (1-42) (human), Amyloid beta-peptide (1-42) (human) supplier, amyloid, β-protein, beta-protein, fragment, β-Amyloid, beta-Amyloid, b-amyloid, Precursor, Protein, APP, Secretase, Peptides, Amyloid, β-peptide, beta-peptide, (1-42), (human), amyloidbeta, amyloidb, amyloidβ, Beta, 1428, Tocris Bioscience

6 篇 Amyloid β-Peptide (1-42) (human) 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Amyloid β-Peptide (1-42) (human) 的部分引用包括:

Chen and Chai (2019) Matriptase cleaves the amyloid-beta peptide 1-42 at Arg-5, Lys-16, and Lys-28. BMC Res Notes 12 5 PMID: 30606244

Mouchard et al (2019) ApoE-fragment/Aβ heteromers in the brain of patients with Alzheimer's disease. Sci Rep 9 3989 PMID: 30850702

Pourbadie et al (2015) Preventing effect of L-type calcium channel blockade on electrophysiological alterations in dentate gyrus granule cells induced by entorhinal amyloid pathology. J Neuroinflammation 10 e0117555 PMID: 25689857

Hui et al (2016) Non-Neuronal Cells Are Required to Mediate the Effects of Neuroinflammation: Results from a Neuron-Enriched Culture System. PLoS One 11 e0147134 PMID: 26788729


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Amyloid β-Peptide (1-42) (human) 的评论

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Great product for inflammation testing..
By Eric Dyne on 09/24/2020
分析类型: In Vitro
种属: Human
细胞系/组织: Microglia

I used this peptide to induce aggregation along with several other brands. The tocris beta-amyloid reacted the best with Thioflavin-T (1uM) in my experience however, I did find the bachem sample seemed to have the best aggregation patterns.

I used a stationary incubator at 30C and a mixture in an upcoming manuscript that promoted optimal aggregation that was reproducible. I did not use DMSO or water but a special phosphate buffer with alkaline solution.

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