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Submit ReviewAmyloid β-Peptide (1-42) (human)
说明： Predominant amyloid β-protein fragment
纯度： ≥95% (HPLC)
生物活性 for Amyloid β-Peptide (1-42) (human)
Amyloid β-Peptide (1-42) (human) is a human form of the predominant amyloid β-peptide found in the brains of patients with Alzheimer's disease. Downregulates bcl-2 and increases the levels of bax. Neurotoxic.
Control Peptide also available.
技术数据 for Amyloid β-Peptide (1-42) (human)
| 分子量 | 4514.08 |
| 公式 | C203H311N55O60S |
| 序列 | DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 107761-42-2 |
| PubChem ID | 16135558 |
| InChI Key | DZHSAHHDTRWUTF-SIQRNXPUSA-N |
| Smiles | [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Amyloid β-Peptide (1-42) (human)
| 溶解性 | Soluble to 1 mg/ml in 50mM Tris buffer |
产品说明书 for Amyloid β-Peptide (1-42) (human)
参考文献 for Amyloid β-Peptide (1-42) (human)
参考文献是支持产品生物活性的出版物。
Glenner and Wong (1984) Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem.Biophys.Res.Commun. 120 885 PMID: 6375662
Paradis et al (1996) Amyloid beta peptide of Alzheimer's disease downregulates bcl-2 and upregulates bax expression in human neurons. J.Neurosci. 16 7533 PMID: 8922409
Van Nostrand et al (1996) Amyloid β-protein induces the cerebrovascular cellular pathology of Alzheimer's disease and related disorders. Ann.N.Y.Acad.Sci. 777 297 PMID: 8624102
If you know of a relevant reference for Amyloid β-Peptide (1-42) (human), please let us know.
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关键词: Amyloid beta-peptide (1-42) (human), Amyloid beta-peptide (1-42) (human) supplier, amyloid, β-protein, beta-protein, fragment, β-Amyloid, beta-Amyloid, b-amyloid, Precursor, Protein, APP, Secretase, Peptides, Amyloid, β-peptide, beta-peptide, (1-42), (human), amyloidbeta, amyloidb, amyloidβ, Beta, 1428, Tocris Bioscience
6 篇 Amyloid β-Peptide (1-42) (human) 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Amyloid β-Peptide (1-42) (human) 的部分引用包括：
Pourbadie et al (2015) Preventing effect of L-type calcium channel blockade on electrophysiological alterations in dentate gyrus granule cells induced by entorhinal amyloid pathology. J Neuroinflammation 10 e0117555 PMID: 25689857
Hui et al (2016) Non-Neuronal Cells Are Required to Mediate the Effects of Neuroinflammation: Results from a Neuron-Enriched Culture System. PLoS One 11 e0147134 PMID: 26788729
Scuderi et al (2012) Palmitoylethanolamide exerts neuroprotective effects in mixed neuroglial cultures and organotypic hippocampal slices via peroxisome proliferator-activated receptor-α. Dent Res J (Isfahan) 9 49 PMID: 22405189
Deléglise et al (2014) β-amyloid induces a dying-back process and remote trans-synaptic alterations in a microfluidic-based reconstructed neuronal network. Acta Neuropathol Commun 2 145 PMID: 25253021
Chen and Chai (2019) Matriptase cleaves the amyloid-beta peptide 1-42 at Arg-5, Lys-16, and Lys-28. BMC Res Notes 12 5 PMID: 30606244
Mouchard et al (2019) ApoE-fragment/Aβ heteromers in the brain of patients with Alzheimer's disease. Sci Rep 9 3989 PMID: 30850702
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Amyloid β-Peptide (1-42) (human) 的评论
平均评分: 5 (Based on 1 Review.)
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Great product for inflammation testing..
By
Eric Dyne on 09/24/2020
分析类型： In Vitro
种属： Human
细胞系/组织： Microglia
I used this peptide to induce aggregation along with several other brands. The tocris beta-amyloid reacted the best with Thioflavin-T (1uM) in my experience however, I did find the bachem sample seemed to have the best aggregation patterns.
I used a stationary incubator at 30C and a mixture in an upcoming manuscript that promoted optimal aggregation that was reproducible. I did not use DMSO or water but a special phosphate buffer with alkaline solution.
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Alzheimer's Disease Poster
Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.