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Apigenin

Cat. No. 1227 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1227 has been discontinued.

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说明： Protein kinase inhibitor
化学名： 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
纯度： ≥97% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 说明书 参考文献

生物活性 for Apigenin

Apigenin is a protein kinase inhibitor. Suppresses tumor-promoting effects of TPA and exhibits antiproliferative activity in human breast cancer cells (IC50 values are 59.44 and 31.15 μM at 24 and 72 hrs respectively). Activates both the intrinsic and extrinsic apoptotic pathways and displays anti-inflammatory, hypotensive, antispasmodic and antioxidant properties in vivo.

技术数据 for Apigenin

分子量 270.2
公式 C15H10O5
储存 Desiccate at +4°C
纯度 ≥97% (HPLC)
CAS Number 520-36-5
PubChem ID 5280443
InChI Key KZNIFHPLKGYRTM-UHFFFAOYSA-N
Smiles OC1=CC=C(C=C1)C1=CC(=O)C2=C(O1)C=C(O)C=C2O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Apigenin

参考文献是支持产品生物活性的出版物。

Choi et al (2009) Apigen induces apoptosis through a mitochondria/caspase-pathway in human breast cancer MDA-MB-453 cells. J.Clin.Biochem.Nutr. 44 260 PMID: 19430615

Jin et al (2009) Apigenin protects endothelium-dependent relaxation of rat aorta against oxidative stress. Eur.J.Pharmacol. 616 200 PMID: 19549516

Kuo and Yang (1995) Reversion of v-H-ras-transformed NIH3T3 cells by apigenin through inhibiting mitogen activated protein kinase and its downstream oncogenes. Biochem.Biophys.Res.Commun. 212 767 PMID: 7626110

Lin et al (1997) Suppression of protein kinase C and nuclear oncogene expression as possible molecular mechanisms of cancer chemoprevention by apigenin and curcumin. J.Cell.Biochem.Suppl. 28-29 39 PMID: 9589348

Sato et al (1994) Apigenin induces morphological differentiation and G2-M arrest in rat neuronal cells. Biochem.Biophys.Res.Commun. 204 578 PMID: 7980517

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关键词: Apigenin, Apigenin supplier, Protein, kinase, inhibitors, inhibits, Kinases, Broad, Spectrum, Kinase, Inhibitors, IRE1, 1227, Tocris Bioscience

1 篇 Apigenin 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Apigenin 的部分引用包括：

Lim et al (2006) Growth inhibition and apoptosis by (-)-epicatechin gallate are mediated by cyclin D1 suppression in head and neck squamous carcinoma cells. J Neurosci 42 3260 PMID: 17045795

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