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Argatroban

Cat. No. 1637 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent thrombin inhibitor
化学名： (2R,4R)-1-[(2S)-5-[(aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-2-piperidinecarboxylic acid
纯度： ≥99% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Argatroban

Argatroban is a potent inhibitor of thrombin mediated fibrinogen cleavage (Ki = 19 nM). Competitive inhibitor of thrombin-induced platelet activation and clotting. Shown to exhibit antithrombotic activity in animal models.

This compound is a mixture of 2 diastereomers (approximate ratio 65/35).

化合物库 for Argatroban

Argatroban is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Argatroban

分子量 508.63
公式 C23H36N6O5S
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 74863-84-6
PubChem ID 6604954
InChI Key CQTDZUSQSTUZDA-UHFFFAOYSA-M
Smiles O=C(N1[C@@H]([C@@](O)=O)C[C@H](C)CC1)[C@@H](NS(C2=CC=CC3=C2NCC(C)C3)(=O)=O)CCCNC(N)=N

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Argatroban

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 50.86 100
1eq. HCl 5.09 10

制备储备液 for Argatroban

以下数据基于产品分子量 508.63。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.97 mL 9.83 mL 19.66 mL
5 mM 0.39 mL 1.97 mL 3.93 mL
10 mM 0.2 mL 0.98 mL 1.97 mL
50 mM 0.04 mL 0.2 mL 0.39 mL

Molarity Calculator

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Dilution Calculator

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参考文献 for Argatroban

参考文献是支持产品生物活性的出版物。

Kikumoto et al (1984) Selective inhibition of thrombin by (2R,4R)-4-methyl-1-[N2-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl++ +) sulfonyl]-1-arginyl)]-2-piperidinecarboxylic acid. Biochemistry 23 85 PMID: 6691968

Jang et al (1990) Prevention of platelet-rich arterial thrombosis by selective thrombin inhibition. Circulation 81 219 PMID: 2297828

Fitzgerald and Fitzgerald (1989) Role of thrombin and thromboxane A2 in reocclusion following coronary thrombolysis with tissue-type plasminogen activator. Proc.Natl.Acad.Sci.USA 86 7585

If you know of a relevant reference for Argatroban, please let us know.

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关键词: Argatroban, Argatroban supplier, Potent, inhibitors, thrombin, fibrinogen, inhibits, antithrombitic, Other, Proteases, 1637, Tocris Bioscience

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