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Auxin

Cat. No. 6834 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Chemical dimerizer used in auxin-inducible degron (AID) system; phytohormone
化学名： 1H-Indole-3-acetic acid
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Auxin

Auxin is a chemical dimerizer used in auxin-inducible degron (AID) systems. Induces degradation of a target protein tagged with the auxin-receptor F-box protein Tir1 E3 ligase AID in human colorectral cancer and mouse ES cells or tagged with AFB2 in A431 cells. Endogenous plant hormone.

技术数据 for Auxin

分子量 175.18
公式 C10H9NO2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 87-51-4
PubChem ID 802
InChI Key SEOVTRFCIGRIMH-UHFFFAOYSA-N
Smiles OC(CC1=CNC2=C1C=CC=C2)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Auxin

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 17.52 100
ethanol 17.52 100

制备储备液 for Auxin

以下数据基于产品分子量 175.18。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 5.71 mL 28.54 mL 57.08 mL
5 mM 1.14 mL 5.71 mL 11.42 mL
10 mM 0.57 mL 2.85 mL 5.71 mL
50 mM 0.11 mL 0.57 mL 1.14 mL

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参考文献 for Auxin

参考文献是支持产品生物活性的出版物。

Nishimura et al (2009) An auxin-based degron system for the rapid depletion of proteins in nonplant cells. Nat.Methods 6 917 PMID: 19915560

Natsume et al (2016) Rapid protein depletion in human cells by auxin-inducible degron tagging with short homology donors. Cell Rep. 15 210 PMID: 27052166

Li et al (2019) An efficient auxin-inducible degron system with low basal degradation in human cells. Nat.Methods. 16 866 PMID: 31451765

If you know of a relevant reference for Auxin, please let us know.

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关键词: Auxin, Auxin supplier, Auxin-inducible, degron, AID, targeted, protein, degradation, TPD, chemical, dimerizer, TIR1, phytohormone, Protein, Dimerizers, Biochemicals, and, Molecular, Biology, Glues, 6834, Tocris Bioscience

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