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Auxinole

Cat. No. 7894 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Auxin antagonist of TIR1/AFB receptors; also OsTIR1 inhibitor in auxin-inducible degron (AID) system
化学名： α-[2-(2,4-Dimethylphenyl)-2-oxoethyl]-1H-indole-3-acetic acid
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Auxinole

Auxinole is an auxin antagonist of TIR1/AFB receptors. Binds to TIR1 to block the formation of the TIR1-IAA-Aux/IAA complex and inhibit auxin-responsive gene expression. Auxinole competitively inhibits various auxin responses in planta. Auxinole also inhibits OsTIR1 that suppresses leaky degradation of degron-fused proteins. Can be used as a control compound with 5-Ph-IAA (Cat. No. 7392) in the AID2 degron system to switch off degradation.

技术数据 for Auxinole

分子量 321.37
公式 C20H19NO3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 86445-22-9
PubChem ID 13077496
InChI Key HGUYAIJBXSQXGV-UHFFFAOYSA-N
Smiles O=C(O)C(C1=CNC=2C=CC=CC21)CC(=O)C3=CC=C(C=C3C)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Auxinole

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 32.14 100
ethanol 6.43 20 温和加热

制备储备液 for Auxinole

以下数据基于产品分子量 321.37。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.11 mL 15.56 mL 31.12 mL
5 mM 0.62 mL 3.11 mL 6.22 mL
10 mM 0.31 mL 1.56 mL 3.11 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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参考文献 for Auxinole

参考文献是支持产品生物活性的出版物。

Hayashi et al (2012) Rational design of an auxin antagonist of the SCF(TIR1) auxin receptor complex. ACS Chem.Biol. 7 590 PMID: 22234040

Yesbolatova et al (2019) Generation of conditional auxin-inducible degron (AID) cells and tight control of degron-fused proteins using the degradation inhibitor auxinole. Methods 164 73 PMID: 31026591

If you know of a relevant reference for Auxinole, please let us know.

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关键词: Auxinole, Auxinole supplier, Auxin, AID, targeted, protein, degradation, degron, TPD, chemical, TIR1, phytohormone, degrade, degraders, DNA,, RNA, and, Protein, Synthesis, Molecular, Glues, 7894, Tocris Bioscience

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