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AZD 2858

Cat. No. 7650 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Highly potent GSK-3 inhibitor; inhibits tau phosphorylation
化学名： 3-Amino-6-[4-[(4-methyl-1-piperazinyl)sulfonyl]phenyl]-N-3-pyridinyl-2-pyrazinecarboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
文献 (4)
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for AZD 2858

AZD 2858 is a potent glycogen synthase kinase-3 (GSK-3) inhibitor (IC50 values are 0.9 and 5 nM for GSK-3α and GSK-3β, respectively). AZD 2858 inhibits tau phosphorylation in vitro (IC50 = 76 nM), improves fracture healing and increases bone mass in rodent models of bone fracture. Also activates Wnt signaling in vitro and in vivo. Brain permeable and orally bioavailable.

技术数据 for AZD 2858

分子量 453.52
公式 C21H23N7O3S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 486424-20-8
PubChem ID 10138980
InChI Key FHCSBLWRGCOVPT-UHFFFAOYSA-N
Smiles O=C(NC=1C=NC=CC1)C=2N=C(C=NC2N)C3=CC=C(C=C3)S(=O)(=O)N4CCN(C)CC4

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AZD 2858

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 4.54 10

制备储备液 for AZD 2858

以下数据基于产品分子量 453.52。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.1 mM 22.05 mL 110.25 mL 220.5 mL
0.5 mM 4.41 mL 22.05 mL 44.1 mL
1 mM 2.2 mL 11.02 mL 22.05 mL
5 mM 0.44 mL 2.2 mL 4.41 mL

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参考文献 for AZD 2858

参考文献是支持产品生物活性的出版物。

Sisask et al (2013) Rats treated with AZD2858, a GSK3 inhibitor, heal fractures rapidly without endochondral bone formation. Bone 54 126 PMID: 23337038

Berg et al (2012) Discovery of novel potent and highly selective glycogen synthase kinase-3β (GSK3β) inhibitors for Alzheimer's disease: design, synthesis, and characterization of pyrazines. J.Med.Chem. 55 9107 PMID: 22489897

Cook et al (2014) Wnt-dependent osteogenic commitment of bone marrow stromal cells using a novel GSK3β inhibitor. Stem Cell Res. 12 415 PMID: 24382458

If you know of a relevant reference for AZD 2858, please let us know.

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关键词: AZD 2858, AZD 2858 supplier, AZD2858, AR28, glycogen, synthases, kinases, 3a, 3b, 3alpha, 3beta, inhibitors, inhibits, alzheimers, tau, phosphorylation, wnt, signaling, signalling, Glycogen, Synthase, Kinase, 3, Other, Wnt, Signaling, 7650, Tocris Bioscience

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