AZD 8055

Cat. No. 7840 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Highly potent and selective mTOR inhibitor

化学名： 5-[2,4-Bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol

纯度： ≥98% (HPLC)

文献 (2)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for AZD 8055

AZD 8055 is a highly potent, selective and ATP-competitive mTOR inhibitor (IC₅₀ = 0.8 nM). Inhibits growth and induces autophagy in a range of cancer cell lines and xenografts, including NSCLC and glioblastoma (IC₅₀ values are 20, 50 and 53 nM in H838, A549 and U87MG cell lines, respectively). Orally bioavailable.

技术数据 for AZD 8055

分子量	465.55
公式	C₂₅H₃₁N₅O₄
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	1009298-09-2
PubChem ID	25262965
InChI Key	KVLFRAWTRWDEDF-IRXDYDNUSA-N
Smiles	C[C@@H]1N(CCOC1)C2=NC(N3[C@H](COCC3)C)=NC4=C2C=CC(C5=CC(CO)=C(C=C5)OC)=N4

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AZD 8055

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	46.55	100
	ethanol	9.31	20

制备储备液 for AZD 8055

以下数据基于产品分子量 465.55。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.15 mL	10.74 mL	21.48 mL
5 mM	0.43 mL	2.15 mL	4.3 mL
10 mM	0.21 mL	1.07 mL	2.15 mL
50 mM	0.04 mL	0.21 mL	0.43 mL

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产品说明书 for AZD 8055

分析证书/产品说明书

化学品安全技术说明书

参考文献 for AZD 8055

参考文献是支持产品生物活性的出版物。

Chresta et al (2010) AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity. Cancer Res. 70 288 PMID: 20028854

If you know of a relevant reference for AZD 8055, please let us know.

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关键词: AZD 8055, AZD 8055 supplier, AZD8055, highly, potent, selective, ATP-competitive, mtor, inhibitor, inhibitors, autophagy, cancer, mTOR, 7840, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Cancer Metabolism Research Product Guide

This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:

Glycolysis
Tricarboxylic Acid Cycle
Lipidogenesis
1C Metabolism and Nucleic Acid Synthesis
Drivers of Metabolic Reprogramming
pH and Redox Balance

Cancer Metabolism Poster

This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.

Pathways for AZD 8055

mTOR Signaling Pathway

mTOR is a serine/threonine kinase that nucleates at multiprotein complexes mTORC1 and mTORC2. Signaling by these complexes regulates cell growth, proliferation and survival.