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BAM 15

Cat. No. 5737 3 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Mitochondrial protonophore uncoupler
化学名： N5,N6-bis(2-Fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine
纯度： ≥98% (HPLC)
说明书
引用文献 (3)
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for BAM 15

BAM 15 is a mitochondrial protonophore uncoupler; uncouples oxidative phosphorylation in L6 myoblast mitochondria in vitro (EC50 = 270 nM). Does not depolarize the plasma membrane. Protects mice from acute renal ischemic-reperfusion injury.

化合物库 for BAM 15

BAM 15 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for BAM 15

分子量 340.29
公式 C16H10F2N6O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 210302-17-3
PubChem ID 565708
InChI Key OEGJBRZAJRPPHL-UHFFFAOYSA-N
Smiles FC1=C(C=CC=C1)NC2=NC3=NON=C3N=C2NC4=C(C=CC=C4)F

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BAM 15

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 34.03 100

制备储备液 for BAM 15

以下数据基于产品分子量 340.29。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.94 mL 14.69 mL 29.39 mL
5 mM 0.59 mL 2.94 mL 5.88 mL
10 mM 0.29 mL 1.47 mL 2.94 mL
50 mM 0.06 mL 0.29 mL 0.59 mL

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产品说明书 for BAM 15

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for BAM 15

参考文献是支持产品生物活性的出版物。

Kenwood et al (2015) Structure-activity relationships of furazano[3,4-b]pyrazines as mitochondrial uncouplers. Bioorg.Med.Chem.Lett. 25 4858 PMID: 26119501

Kenwood et al (2013) Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane. Mol.Metab. 3 114 PMID: 24634817

Axelrod et al (2020) BAM15-mediated mitochondrial uncoupling protects against obesity and improves glycemic control. EMBO Mol.Med. doi: 10.15252 PMID: 32519812

If you know of a relevant reference for BAM 15, please let us know.

按标靶查看相关产品

关键词: BAM 15, BAM 15 supplier, BAM15, mitochondrial, uncouplers, oxidative, phosphorylation, respiration, protonophores, renal, ischemic-reperfusion, injury, Oxidative, Phosphorylation, 5737, Tocris Bioscience

3 篇 BAM 15 的引用文献

引用文献是使用了 Tocris 产品的出版物。 BAM 15 的部分引用包括：

Panja et al (2019) Paraneoplastic cerebellar degeneration: Yo antibody alters mitochondrial calcium buffering capacity. Neuropathol Appl Neurobiol 45 141 PMID: 29679372

Styr et al (2019) Mitochondrial Regulation of the Hippocampal Firing Rate Set Point and Seizure Susceptibility. Neuron 102 1009 PMID: 31047779

Wei et al (2018) iPSCs from a Hibernator Provide a Platform for Studying Cold Adaptation and Its Potential Medical Applications. Cell 173 851-863.e16 PMID: 29576452

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