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Submit ReviewBAY 293
说明： Potent KRas/SOS1 interaction inhibitor
化学名： (R)-6,7-Dimethoxy-2-methyl-N-[1-[4-[2-[(methylamino)methyl]phenyl]thiophene-2-yl]ethyl]quinazolin-4-amine
纯度： ≥98% (HPLC)
生物活性 for BAY 293
BAY 293 is a potent KRas/son of sevenless 1 (SOS1) interaction inhibitor (IC50 = 21 nM); active R-enantiomer. Downregulates active RAS in tumor cells. Inhibits RAS-RAF-MEK-ERK pathway. Exhibits synergistic effects with KRASG12C inhibitor ARS-853.
Negative control also available.
许可信息
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY 293 probe summary on the SGC website.
化合物库 for BAY 293
BAY 293 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for BAY 293
| 分子量 | 448.59 |
| 公式 | C25H28N4O2S |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 2244904-70-7 |
| InChI Key | WEGLOYDTDILXDA-OAHLLOKOSA-N |
| Smiles | CNCC1=C(C=CC=C1)C1=CSC(=C1)[C@@H](C)NC1=NC(C)=NC2=C1C=C(OC)C(OC)=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for BAY 293
参考文献 for BAY 293
参考文献是支持产品生物活性的出版物。
Hillig et al (2019) Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction. Proc.Natl.Acad.Sci.USA. 116 2551 PMID: 30683722
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关键词: BAY 293, BAY 293 supplier, BAY293, Potent, KRas/son, of, sevenless, 1, SOS1, interaction, inhibitors, inhibits, Ras, GTPases, 6857, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Cancer Metabolism Research Product Guide
This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:
- Glycolysis
- Tricarboxylic Acid Cycle
- Lipidogenesis
- 1C Metabolism and Nucleic Acid Synthesis
- Drivers of Metabolic Reprogramming
- pH and Redox Balance
RAS Oncoproteins Scientific Review
Written by Kirsten L. Bryant, Adrienne D. Cox and Channing J. Der, this review provides a comprehensive overview of RAS protein function and RAS mutations in cancer. Key signaling pathways are highlighted and therapeutic vulnerabilities are explored. This review also includes a detailed section on RAS drug discovery and targeting synthetic lethal interactors of mutant RAS. Compounds available from Tocris are listed.
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.
Epigenetics in Cancer Poster
This poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.
Pathways for BAY 293
Akt Signaling Pathway
The Akt signaling pathway plays a key role in the mediation of protein synthesis, metabolism, proliferation and cell cycle progression. It may be referred to as a 'prosurvival' pathway.