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BAY 87-2243

Cat. No. 6980 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6980 has been discontinued.

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说明： Mitochondrial complex I inhibitor
化学名： 1-Cyclopropyl-4-[4-[[5-methyl-3-[3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]-1H-pyrazol-1-yl]methyl]-2-pyridinyl]piperazine
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for BAY 87-2243

BAY 87-2243 is a mitochondrial complex I inhibitor. Exhibits no effect on mitochondrial complex III. Induces mitochondrial permeability transition pore (mPTP) opening, stimulates autophagosome formation and mitophagy, and increases ROS levels. Activates necroptotic and ferroptotic cell death. Also inhibits hypoxia-induced gene activation. Induces cell death in melanoma cell lines in vitro and exhibits antitumor activity in a mouse NSCLC xenograft model in vivo.

化合物库 for BAY 87-2243

BAY 87-2243 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for BAY 87-2243

分子量 525.54
公式 C26H26F3N7O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1227158-85-1
PubChem ID 67377767
InChI Key CDJNNOJINJAXPV-UHFFFAOYSA-N
Smiles CC1=CC(=NN1CC1=CC=NC(=C1)N1CCN(CC1)C1CC1)C1=NC(=NO1)C1=CC=C(OC(F)(F)F)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for BAY 87-2243

参考文献是支持产品生物活性的出版物。

Basit et al (2017) Mitochondrial complex I inhibition triggers a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis in melanoma cells. Cell Death Dis. 8 e2716 PMID: 28358377

Ellinghaus et al (2013) BAY 87-2243, a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I. Cancer Med. 2 611 PMID: 24403227

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关键词: BAY 87-2243, BAY 87-2243 supplier, BAY87-2243, Hypoxia, inducible, factor, HIF, 1alpha, alfa, mitochondrial, complex, I, inhibitors, inhibits, Oxidative, Phosphorylation, 6980, Tocris Bioscience

1 篇 BAY 87-2243 的引用文献

引用文献是使用了 Tocris 产品的出版物。 BAY 87-2243 的部分引用包括：

Won Do et al (2021) Mitofusin-2 boosts innate immunity through the maintenance of aerobic glycolysis and activation of xenophagy in mice. Commun Biol 4 548 PMID: 33972668

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Cancer Metabolism Research Product Guide

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