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Bendamustine hydrochloride

Cat. No. 3681 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Cytostatic agent; exhibits DNA alkylating and purine analog properties
化学名： 5-[Bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid hydrochloride
纯度： ≥98% (HPLC)
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引用文献
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文献 (1)
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Bendamustine hydrochloride

Bendamustine hydrochloride is a cytostatic agent that displays activity in non-Hodgkin's lymphomas. Exhibits bifunctionality; combines DNA alkylating properties with those of purine analogs.

技术数据 for Bendamustine hydrochloride

分子量 394.72
公式 C16H21Cl2N3O2.HCl
储存 Desiccate at RT
纯度 ≥98% (HPLC)
CAS Number 3543-75-7
PubChem ID 77082
InChI Key ZHSKUOZOLHMKEA-UHFFFAOYSA-N
Smiles CN2C1=CC=C(N(CCCl)CCCl)C=C1N=C2CCCC(O)=O.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Bendamustine hydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 9.87 25
DMSO 39.47 100

制备储备液 for Bendamustine hydrochloride

以下数据基于产品分子量 394.72。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.53 mL 12.67 mL 25.33 mL
5 mM 0.51 mL 2.53 mL 5.07 mL
10 mM 0.25 mL 1.27 mL 2.53 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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产品说明书 for Bendamustine hydrochloride

分析证书/产品说明书
化学品安全技术说明书

参考文献 for Bendamustine hydrochloride

参考文献是支持产品生物活性的出版物。

Schwanen et al (2002) In vitro evaluation of bendamu. induced apoptosis in B-chronic lymphocytic leukemia. Leukemia. 16 2096 PMID: 12357363

Keating et al (2008) Bendamustine. Nat.Rev.Drug Discov. 7 473 PMID: 18511926

Masiello and Tulpule (2009) Bendamustine therapy in chronic lymphocytic leukemia. Expert Opin.Pharmacother. 10 1687 PMID: 19527193

If you know of a relevant reference for Bendamustine hydrochloride, please let us know.

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篇 Bendamustine hydrochloride 的引用文献

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Bendamustine termporarily halts growth of melanoma cells in vitro.
By Anonymous on 02/14/2019
分析类型： In Vitro
种属： Human

Bendamustine was used at a 20 uM concentration for in vitro culture with SK-MEL-28 and cell viability was monitored over time with live imaging. Arrow indicates when compound was added to media.

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Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for Bendamustine hydrochloride

Apoptosis Signaling Pathway

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.