BIBO 3304 trifluoroacetate

Cat. No. 2412 11 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Highly selective NPY Y₁ receptor antagonist

化学名： N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamide ditrifluoroacetate

纯度： ≥98% (HPLC)

引用文献 (11)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for BIBO 3304 trifluoroacetate

BIBO 3304 trifluoroacetate is a high affinity NPY Y₁ receptor antagonist (IC₅₀ values are 0.38 and 0.72 nM at human and rat receptors respectively) that displays > 2600-fold selectivity over Y₂, Y₄ and Y₅ receptors. Inhibits NPY- and fasting-induced feeding in vivo following central administration. Also antagonizes anxiolytic-like effects of NPY.

化合物库 for BIBO 3304 trifluoroacetate

BIBO 3304 trifluoroacetate is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for BIBO 3304 trifluoroacetate

分子量	757.69
公式	C₂₉H₃₅N₇O₃.2CF₃CO₂H
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	2310085-85-7
PubChem ID	5311022
InChI Key	TVMJSGGZULFVCZ-XMMPIXPASA-N
Smiles	OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.NC(=N)NCCC[C@@H](NC(=O)C(C1=CC=CC=C1)C1=CC=CC=C1)C(=O)NCC1=CC=C(CNC(N)=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BIBO 3304 trifluoroacetate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	75.77	100
	ethanol	15.15	20

制备储备液 for BIBO 3304 trifluoroacetate

以下数据基于产品分子量 757.69。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.32 mL	6.6 mL	13.2 mL
5 mM	0.26 mL	1.32 mL	2.64 mL
10 mM	0.13 mL	0.66 mL	1.32 mL
50 mM	0.03 mL	0.13 mL	0.26 mL

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产品说明书 for BIBO 3304 trifluoroacetate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for BIBO 3304 trifluoroacetate

参考文献是支持产品生物活性的出版物。

Wieland et al (1998) Subtype selectivity of the novel nonpeptide neuropeptide Y Y1 receptor antagonist BIBO 3304 and its effect on feeding in rodents. Br.J.Pharmacol. 125 549 PMID: 9806339

Sajdyk et al (1999) Amygdalar neuropeptide Y Y1 receptors mediate the anxiolytic-like actions of neuropeptide Y in the social interaction test. Eur.J.Pharmacol. 368 143 PMID: 10193650

Lecklin et al (2002) Receptor subtypes Y₁ and Y₅ mediate neuropeptide Y induced feeding in the guinea-pig. Br.J.Pharmacol. 135 2029 PMID: 11959807

If you know of a relevant reference for BIBO 3304 trifluoroacetate, please let us know.

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关键词: BIBO 3304 trifluoroacetate, BIBO 3304 trifluoroacetate supplier, selective, NPY, Y1, receptor, antagonists, Neuropeptide, Y, Receptors, BIBO3304, trifluoroacetate, neuropeptides, 2412, Tocris Bioscience

11 篇 BIBO 3304 trifluoroacetate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 BIBO 3304 trifluoroacetate 的部分引用包括：

Martins et al (2015) Activation of Neuropeptide Y Receptors Modulates Retinal Ganglion Cell Physiology and Exerts Neuroprotective Actions In Vitro. ASN Neuro 7 PMID: 26311075

Panaro et al (2014) The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo. Neuropsychopharmacology 20 1018 PMID: 25453189

Sanchez et al (2021) Photo-induced receptor confinement drives ligand-independent GPCR signaling. Science 371 PMID: 33632896

Choi et al (2019) Elevated Neuropeptide Y in Endothelial Dysfunction Promotes Macrophage Infiltration and Smooth Muscle Foam Cell Formation. Front Immunol 10 1701 PMID: 31379881

Pickens et al (2009) Effect of pharmacological manipulations of neuropeptide Y and corticotropin-releasing factor neurotransmission on incubation of conditioned fear. Neuroscience 164 1398 PMID: 19800945

Chen et al (2012) Activation of NPY receptors suppresses excitatory synaptic transmission in a taste-feeding network in the lower brain stem. Am J Physiol Regul Integr Comp Physiol 302 R1401 PMID: 22513746

Kojima et al (2012) A role for endogenous peptide YY in tachykinin NK(2) receptor-triggered 5-HT release from guinea pig isolated colonic mucosa. Br J Pharmacol 167 1362 PMID: 22758653

Maymon et al (2019) Neuropeptide Y and cannabinoids interaction in the amygdala after exposure to shock and reminders model of PTSD Neuropharmacology 162 PMID: 31622603

Alhadeff et al (2018) A Neural Circuit for the Suppression of Pain by a Competing Need State. Cell 173 140 PMID: 29570993

Atasoy et al (2012) Deconstruction of a neural circuit for hunger. Cell Metab 488 172 PMID: 22801496

Cohen et al (2015) Diurnal fluctuations in HPA and neuropeptide Y-ergic systems underlie differences in vulnerability to traumatic stress responses at different zeitgeber times. J Neurosci 40 774 PMID: 25241802

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