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Submit ReviewBIO-acetoxime
说明： Selective GSK-3α/β inhibitor
化学名： (2'Z,3'E)-6-Bromoindirubin-3'-acetoxime
纯度： ≥98% (HPLC)
生物活性 for BIO-acetoxime
BIO-acetoxime is a selective GSK-3α/β inhibitor (IC50 values are 0.01, 2.4, 4.3 and 63 μM for GSK-3α/β, CDK5/p25, CDK2/cyclin A and CDK1/cyclin B respectively). Induces Wnt signaling and inhibits CD8+ T cell effector differentiation.
技术数据 for BIO-acetoxime
| 分子量 | 398.21 |
| 公式 | C18H12BrN3O3 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 667463-85-6 |
| PubChem ID | 24906283 |
| InChI Key | ORWSYHWTBSHFIV-UHFFFAOYSA-N |
| Smiles | O=C(NC4=C3C=CC(Br)=C4)/C3=C2NC1=CC=CC=C1/C/2=N\OC(C)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for BIO-acetoxime
参考文献 for BIO-acetoxime
参考文献是支持产品生物活性的出版物。
Meijer et al (2003) GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chem.Biol. 10 1255 PMID: 14700633
Polychronopoulos et al (2004) Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases. J.Med.Chem. 47 935 PMID: 14761195
Gattinoni et al (2009) Wnt signaling arrests T cell differentiation and generates CD8+ memory stem cells. Nat.Med. 15 808 PMID: 19525962
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关键词: BIO-acetoxime, BIO-acetoxime supplier, BIO-acetoxime, glycogen, synthase, kinases, 3, GSK-3, GSK3, Gsk3alpha/beta, GSK3beta, inhibitors, inhibits, selective, Glycogen, Synthase, Kinase, Stem, Cell, Signaling, 3874, Tocris Bioscience
4 篇 BIO-acetoxime 的引用文献
引用文献是使用了 Tocris 产品的出版物。 BIO-acetoxime 的部分引用包括：
Julian et al (2019) FOXA2 Is Required for Enhancer Priming during Pancreatic Differentiation. Cell Rep 28 382-393.e7 PMID: 31291575
Matthew W et al (2019) GSK3 regulates hair cell fate in the developing mammalian cochlea. Dev Biol 453 191-205 PMID: 31185200
Shi et al (2017) Genome Editing in hPSCs Reveals GATA6 Haploinsufficiency and a Genetic Interaction with GATA4 in Human Pancreatic Development. Cell Stem Cell 20 675 PMID: 28196600
Penas et al (2015) GSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation. Sci Rep 14 417 PMID: 25616418
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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Pathways for BIO-acetoxime
