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BMS 299897

Cat. No. 2870 2 篇引用文献 2 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent γ-secretase inhibitor
化学名： 2-[(1R)-1-[[(4-Chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl-5-fluorobenzenebutanoic acid
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论 (2)
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for BMS 299897

BMS 299897 is an orally active, potent γ-secretase inhibitor (IC50 = 12 nM). Inhibits Aβ40 and Aβ42 formation in vitro (IC50 values are 7.4 and 7.9 nM respectively) and reduces Aβ in the brain, plasma and cerebrospinal fluid in vivo. Exhibits no Notch toxicity. Brain penetrant.

化合物库 for BMS 299897

BMS 299897 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for BMS 299897

分子量 511.94
公式 C24H21ClF3NO4S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 290315-45-6
PubChem ID 11249248
InChI Key IZAOBRWCUGOKNH-OAHLLOKOSA-N
Smiles FC1=CC=[C@@]([C@H](N(C3=CC(F)=CC=C3F)S(C2=CC=C(Cl)C=C2)(=O)=O)C)C(CCCC(O)=O)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BMS 299897

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 51.19 100
ethanol 51.19 100

制备储备液 for BMS 299897

以下数据基于产品分子量 511.94。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.95 mL 9.77 mL 19.53 mL
5 mM 0.39 mL 1.95 mL 3.91 mL
10 mM 0.2 mL 0.98 mL 1.95 mL
50 mM 0.04 mL 0.2 mL 0.39 mL

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产品说明书 for BMS 299897

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for BMS 299897

参考文献是支持产品生物活性的出版物。

Barten et al (2005) Dynamics of β-Amyloid reductions in brain, cerebrospinal fluid, and plasma of β-amyloid precursor protein transgenic mice treated with a γ-secretase inhibitor. J.Pharmacol.Exp.Ther. 312 635 PMID: 15452193

Anderson et al (2005) Reductions in β-amyloid concentrations in vivo by the γ-secretase inhibitors BMS-289948 and BMS-299897. Biochem.Pharmacol. 69 689 PMID: 15670587

Goldstein et al (2007) Ex vivo occupancy of the γ-secretase inhibitors correlates with brain β-amyloid peptide reduction in Tg2576 mice. J.Pharmacol.Exp.Ther. 323 102 PMID: 17640949

If you know of a relevant reference for BMS 299897, please let us know.

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关键词: BMS 299897, BMS 299897 supplier, BMS299897, gamma-secretase, inhibits, orally, active, inhibitors, g-secretase, beta-amyloid, b-amyloid, γ-secretase, β-amyloid, amyloidbeta, amyloidb, amyloidβ, Gamma-Secretase, Amyloid, Beta, Peptides, 2870, Tocris Bioscience

2 篇 BMS 299897 的引用文献

引用文献是使用了 Tocris 产品的出版物。 BMS 299897 的部分引用包括：

Liu et al (2018) APP upregulation contributes to retinal ganglion cell degeneration via JNK3. Cell Death Differ 25 661 PMID: 29238071

Pitt et al (2017) Neuroprotective astrocyte-derived Ins/IGF-1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers. Mol Biol Cell 28 2623 PMID: 28963439

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BMS 299897 的评论

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works well.
By Anonymous on 03/26/2020
分析类型： In Vitro
种属： Rat
细胞系/组织： Hippocampal neuron

gamma -secretase (100 nM BMS 299897 and 250 nM DAPT)

review image
BMS as a inhibitor treatment is good for Hippocampal neuron.
By Anonymous on 10/13/2019
分析类型： In Vitro
种属： Human
细胞系/组织： Hippocampal neuron

Using more specific inhibitors, we ruled out the involvement of gamma -secretase (100 nM BMS 299897 and 250 nM DAPT) or matrix metalloproteinases 1, 2, 3, 7, 9, 14, and 17 (0.1–1 μM batimastat and marimastat), as their inhibitors failed to alter A beta O release

PMID: 28963439
review image

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