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Bortezomib

Cat. No. 7282 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： High affinity proteasome inhibitor
化学名： B-[(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic acid
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Bortezomib

Bortezomib is a high affinity proteasome inhibitor (Ki = 0.6 nM). Inhibits growth of multiple myeloma (MM) cell lines (IC50 values in <50 nM range); induces apoptosis in MM cell lines and MM patient derived cells, including p53 mutant cell lines. Decreases adherence of MM cells lines to bone marrow stromal cells (BMSCs). Acts synergistically with dexamethasone (Cat. No. 1126). Also cytotoxic in MCF-7 breast cancer cell line (IC50 = 50 nM).

化合物库 for Bortezomib

Bortezomib is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Bortezomib

分子量 384.24
公式 C19H25BN4O4
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 179324-69-7
PubChem ID 387447
InChI Key GXJABQQUPOEUTA-RDJZCZTQSA-N
Smiles CC(C)C[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C1=NC=CN=C1)B(O)O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Bortezomib

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 50 131
ethanol 10 27

制备储备液 for Bortezomib

以下数据基于产品分子量 384.24。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1.31 mM 1.99 mL 9.93 mL 19.87 mL
6.55 mM 0.4 mL 1.99 mL 3.97 mL
13.1 mM 0.2 mL 0.99 mL 1.99 mL
65.5 mM 0.04 mL 0.2 mL 0.4 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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参考文献 for Bortezomib

参考文献是支持产品生物活性的出版物。

Teicher et al (1999) The proteasome inhibitor PS-341 in cancer therapy. Clin.Cancer Res. 5 2638 PMID: 10499643

Hideshima et al (2001) The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells. Cancer Res. 61 3071 PMID: 11306489

If you know of a relevant reference for Bortezomib, please let us know.

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关键词: Bortezomib, Bortezomib supplier, PS341, proteasome, inhibitor, multiple, myeloma, high, affinity, Proteasome, 7282, Tocris Bioscience

2 篇 Bortezomib 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Bortezomib 的部分引用包括：

Tomo et al (2023) ATP Consumption Is Coupled with Endocytosis in Exudated Neutrophils. Int J Mol Sci 24 PMID: 37240384

Vimla et al (2021) CHIP/STUB1 Ubiquitin Ligase Functions as a Negative Regulator of ErbB2 by Promoting Its Early Post-Biosynthesis Degradation. Cancers (Basel) 13 PMID: 34439093

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia