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Submit ReviewBRD 7389
说明： Ribosomal S6 kinase inhibitor
化学名： 1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione
纯度： ≥97% (HPLC)
生物活性 for BRD 7389
BRD 7389 is a ribosomal S6 kinase (RSK) inhibitor (IC50 values are 1.2, 1.5 and 2.4 μM for RSK3, RSK1 and RSK2 respectively). Upregulates insulin expression in terminally differentiated pancreatic α-cells.
技术数据 for BRD 7389
| 分子量 | 366.41 |
| 公式 | C24H18N2O2 |
| 储存 | Store at -20°C |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 376382-11-5 |
| PubChem ID | 1080352 |
| InChI Key | XASCINRGTHLHGM-UHFFFAOYSA-N |
| Smiles | O=C(C3=C2C(N4)=CC=C3)C1=CC=CC=C1C2=C(NCCC5=CC=CC=C5)C4=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for BRD 7389
参考文献 for BRD 7389
参考文献是支持产品生物活性的出版物。
Fomina-Yadlin et al (2010) Small molecule inducers of Ins expression in pancreatic alpha cells. Proc.Natl.Acad.Sci.U.S.A. 107 15099 PMID: 20696901
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关键词: BRD 7389, BRD 7389 supplier, BRD7389, p90, rsk, ribosomal, s6, kinases, inhibitors, inhibits, rsk1, rsk2, rsk3, RSK, 4037, Tocris Bioscience
3 篇 BRD 7389 的引用文献
引用文献是使用了 Tocris 产品的出版物。 BRD 7389 的部分引用包括：
James B et al (2020) Ancient familial Mediterranean fever mutations in human pyrin and resistance to Yersinia pestis. Nat Immunol 21 857-867 PMID: 32601469
Breindel et al (2013) EGF receptor activates MET through MAPK to enhance non-small cell lung carcinoma invasion and brain metastasis. Cancer Res 73 5053 PMID: 23794705
Davide et al (2018) Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase. Cancer Cell 33 91-107.e6 PMID: 29316436
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