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Submit ReviewBryostatin 1
说明： Protein kinase C activator
别名： NSC 339555
化学名： (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(Acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl-(2E, 4E)-2,4-octadienoic acid ester
纯度： ≥98% (HPLC)
生物活性 for Bryostatin 1
Bryostatin 1 is a protein kinase C (PKC) activator that binds with high affinity (Ki = 1.35 nM). Initially activates and subsequently induces downregulation of PKC isozymes. Sensitizes tumor cells to cytotoxic effects of anticancer agents. Restores hippocampal synapses and spatial learning and memory in an in vivo model of fragile X syndrome.
技术数据 for Bryostatin 1
| 分子量 | 905.04 |
| 公式 | C47H68O17 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 83314-01-6 |
| PubChem ID | 5280757 |
| InChI Key | MJQUEDHRCUIRLF-TVIXENOKSA-N |
| Smiles | O=C(C)O[C@H](C(C)2C)C[C@@H](C[C@@H](O)CC(O[C@@H]([C@H](O)C)C[C@@H](O4)C3)=O)O[C@@]2(O)C[C@H](C1)O[C@@H](/C=C/C(C)(C)[C@@]4(O)[C@@H](OC(/C=C/C=C/CCC)=O)/C3=C/C(OC)=O)C/C1=C\C(OC)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Bryostatin 1
| 溶解性 | Soluble in DMSO and in ethanol |
产品说明书 for Bryostatin 1
参考文献 for Bryostatin 1
参考文献是支持产品生物活性的出版物。
Lorenzo et al (1997) The catalytic domain of protein kinase Cδ confers protection from down-regulation induced by bryostatin 1. J.Biol.Chem. 272 33338 PMID: 9407126
Sun and Alkon (2006) Bryostatin-1: pharmacology and therapeutic potential as a CNS drug. CNS Drug Rev. 12 1 PMID: 16834754
Wender et al (1998) The design, computer modeling, solution structure, and biological evaluation of synthetic analogs of bryostatin 1. Proc.Natl.Acad.Sci.USA 95 6624 PMID: 9618462
Sun et al (2014) Bryostatin-1 restores hippocampal synapses and spatial learning and memory in adult fragile X mice. J Pharmacol Exp Ther. 349 393 PMID: 24659806
If you know of a relevant reference for Bryostatin 1, please let us know.
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关键词: Bryostatin 1, Bryostatin 1 supplier, Protein, kinases, C, activators, PKC, Bryostatin1, NSC339555, NSC, 339555, Kinase, 2383, Tocris Bioscience
6 篇 Bryostatin 1 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Bryostatin 1 的部分引用包括：
Park et al (2016) Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS. Nat Immunol 17 914 PMID: 27270401
Visavadiya (2016) Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3. Cell Communication and Signaling 14 32 PMID: 27978828
Lin et al (2016) Neuronal splicing regulator RBFOX3(NeuN) regulates adult hippocampal neurogenesis and synaptogenesis PLoS One 11 e0164164 PMID: 27701470
Schaffer et al (2018) PKCε Inhibits Neuronal Dendritic Spine Development through Dual Phosphorylation of Ephexin5. Cell Rep 25 2470 PMID: 30485813
Kornberg (2018) Bryostatin-1 alleviates experimental multiple sclerosis. Proc Natl Acad Sci U S A. 115 2186 PMID: 29440425
Marsden (2018) Characterization of designed, synthetically accessible bryostatin analog HIV latency reversing agents. Virology 520 83 PMID: 29800728
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Bryostatin 1 的评论
平均评分: 4 (Based on 1 Review.)
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Mitochondrial bioenergetics measurements by reagent screen.
By
Anonymous on 03/15/2020
分析类型： In Vitro
种属： Mouse
细胞系/组织： mouse brain endothelioma cell line
50 nM
