Camostat mesylate

Name: Camostat mesylate
Brand: Tocris Bioscience
SKU: 3193
Rating: 3 (1 reviews)

Cat. No. 3193 7 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Orally active protease inhibitor; inhibits entry of SARS-Cov-2 into lung cells

化学名： 4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]benzeneacetic acid 2-(dimethylamino)-2-oxoethyl ester methanesulfonate

纯度： ≥98% (HPLC)

说明书

引用文献 (7)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Camostat mesylate

Camostat mesylate is an orally active protease inhibitor. Inhibits trypsin and various inflammatory proteases including plasmin, kallikrein and thrombin. Suppresses pancreatitis-induced pain in rats following oral administration. Also inhibits transmembrane serine protease TMPRSS2 and partially blocks entry of SARS-Cov-2 (COVID-19) into lung cells in vitro.

Tocris products are for biomedical research use only. They are not intended for human or veterinary use.

化合物库 for Camostat mesylate

Camostat mesylate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Camostat mesylate

分子量	494.52
公式	C₂₀H₂₂N₄O₅.CH₃SO₃H
储存	Desiccate at RT
纯度	≥98% (HPLC)
CAS Number	59721-29-8
PubChem ID	43071
InChI Key	FSEKIHNIDBATFG-UHFFFAOYSA-N
Smiles	O=C(C2=CC=C(NC(N)=N)C=C2)OC1=CC=C(CC(OCC(N(C)C)=O)=O)C=C1.CS(=O)(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Camostat mesylate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	24.73	50
	DMSO	49.45	100

制备储备液 for Camostat mesylate

以下数据基于产品分子量 494.52。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.02 mL	10.11 mL	20.22 mL
5 mM	0.4 mL	2.02 mL	4.04 mL
10 mM	0.2 mL	1.01 mL	2.02 mL
50 mM	0.04 mL	0.2 mL	0.4 mL

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产品说明书 for Camostat mesylate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Camostat mesylate

参考文献是支持产品生物活性的出版物。

Horiuchi et al (1990) Gabexate and camostat, synthetic proteinase inhibitors, as direct inducing factors of water and bicarbonate secretion in the isolated and blood-perfused dog pancreas. J.Pharmacol.Exp.Ther. 252 320 PMID: 1688943

Ishikura et al (2007) The proteinase inhibitor camostat mesilate suppresses pancreatic pain in rodents. Life Sci. 80 1999 PMID: 17433371

Hoffmann et al (2020) SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically-proven protease inhibitor. Cell 181 271 PMID: 32142651

If you know of a relevant reference for Camostat mesylate, please let us know.

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