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Capecitabine

Cat. No. 4799 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4799 has been discontinued.

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说明： Prodrug of 5-Fluorouracil (Cat. No. 3257). Inhibits DNA synthesis
别名： Ro 09-1978
化学名： 5'-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine
纯度： ≥98% (HPLC)
说明书
引用文献
评论 (1)
文献 (2)
生物活性 技术数据 说明书 参考文献

生物活性 for Capecitabine

Capecitabine is a prodrug of 5-Fluorouracil (5-FU) (Cat. No. 3257). Selectively activated in tumor cells by thymidine phosphorylase; inhibits DNA synthesis upon conversion to 5-FU. Orally available.

化合物库 for Capecitabine

Capecitabine is also offered as part of the Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Capecitabine

分子量 359.35
公式 C15H22FN3O6
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 154361-50-9
PubChem ID 60953
InChI Key GAGWJHPBXLXJQN-UORFTKCHSA-N
Smiles C[C@H]1O[C@@H](N2C=C(F)C(NC(OCCCCC)=O)=NC2=O)[C@H](O)[C@@H]1O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Capecitabine

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for Capecitabine

参考文献是支持产品生物活性的出版物。

Shimma et al (2000) The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine. Bioorg.Med.Chem.Lett. 8 1697 PMID: 10976516

Desmoulin et al (2002) Metabolism of capecitabine, an oral fluorou. prodrug: 19F NMR studies in animal models and human urine. Drug Metab.Dispos. 30 1221 PMID: 12386128

Bhuyan et al (1972) Cell cycle phase specificity of antitumor agents. Cancer Res. 32 398 PMID: 4258018

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关键词: Capecitabine, Capecitabine supplier, 5-Fluorouracil, prodrugs, 5-FU, DNA, synthesis, inhibitors, inhibits, inhbits, anticancer, Ro09-1978, chemotherapeutics, Ro, 09-1978, DNA,, RNA, and, Protein, Synthesis, 4799, Tocris Bioscience

篇 Capecitabine 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 Capecitabine 的引用文献。

Capecitabine 的评论

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Medium concentrations of capecitabine only weakly slow melanoma growth in vitro.
By Anonymous on 02/14/2019
分析类型： In Vitro
种属： Human

Capecitabine was used at a 20 uM concentration for in vitro culture with SK-MEL-28 and cell viability was monitored over time with live imaging. Arrow indicates when compound was added to media.

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

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