Carboplatin

Name: Carboplatin
Brand: Tocris Bioscience
SKU: 2626
Rating: 4 (1 reviews)

Cat. No. 2626 3 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： DNA cross-linking antitumor agent

别名： NSC 241240,Paraplatin,JM 8

化学名： cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II)

纯度： ≥99% (HPLC)

说明书

引用文献 (3)

文献 (1)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Carboplatin

Carboplatin is an antitumor agent that forms platinum-DNA adducts. Causes intra- and interstrand DNA crosslinks blocking DNA replication and transcription. Enhances radiation-induced single-strand DNA breakage and displays lower nephrotoxicity than analog cisplatin (Cat. No. 2251).

技术数据 for Carboplatin

分子量	371.25
公式	C₆H₁₂N₂O₄Pt
储存	Store at RT
纯度	≥99% (HPLC)
CAS Number	41575-94-4
PubChem ID	10339178
InChI Key	OLESAACUTLOWQZ-UHFFFAOYSA-L
Smiles	O=C(C21CCC2)O[Pt-2]([NH3+])([NH3+])OC1=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Carboplatin

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	9.28	25

制备储备液 for Carboplatin

以下数据基于产品分子量 371.25。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.25 mM	10.77 mL	53.87 mL	107.74 mL
1.25 mM	2.15 mL	10.77 mL	21.55 mL
2.5 mM	1.08 mL	5.39 mL	10.77 mL
12.5 mM	0.22 mL	1.08 mL	2.15 mL

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Reconstitution Calculator

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产品说明书 for Carboplatin

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Carboplatin

参考文献是支持产品生物活性的出版物。

Natarajan et al (1999) Increased DNA-binding activity of cis-1,1-cyclobutanedicarboxylatodiammineplatinum (II) (carboplatin) in the presence of nucleophiles and human breast cancer MCF-7 cell cytoplasmic extracts: activation theory revisited. Biochem.Pharmacol. 58 1625 PMID: 10535754

Thomas et al (2006) High accumulation of platinum-DNA adducts in strial marginal cells of the cochlea is an early event in cisp. but not carbop. ototoxicity. Mol.Pharmacol. 70 23 PMID: 16569706

Yang et al (1995) Carboplatin enhances the production and persistence of radiation-induced DNA single-strand breaks. Radiation Res. 143 302

If you know of a relevant reference for Carboplatin, please let us know.

按标靶查看相关产品

关键词: Carboplatin, Carboplatin supplier, DNA, cross-linking, antitumor, agent, inhibitors, inhibits, synthesis, Apoptosis, Inducer, Synthesis, NSC241240, chemotherapeutics, NSC, 241240, Paraplatin, JM, 8, Inducers, DNA,, RNA, and, Protein, 2626, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Carboplatin, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

3 篇 Carboplatin 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Carboplatin 的部分引用包括：

Ishiguro et al (2016) Cataloging antineoplastic agents according to their effectiveness against platinum-resistant and platinum-sensitive ovarian carcinoma cell lines. J Transl Sci 2 117 PMID: 27076919

Massey (2015) Multiparametric Cell Cycle Analysis Using the Operetta High-Content Imager and Harmony Software with PhenoLOGIC. PLoS One 10 e0134306 PMID: 26218638

Bryant et al (2014) Chk1 inhibition as a novel therapeutic strategy for treating triple-negative breast and ovarian cancers. Cell Death Differ 14 570 PMID: 25104095

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Carboplatin 的评论

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Anti-tumor activity assay.

By Donghee Choi on 01/04/2018

分析类型： In Vitro

种属： Human

Used in in vitro assay to assess anti-tumor activity in combination with other agents

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for Carboplatin

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.