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Submit ReviewCDDO Im
说明： Nrf2 signaling activator
化学名： 1-(2-Cyano-3,12,28-trioxooleana-1,9(11)-dien-28-yl)-1H-imidazole
纯度： ≥98% (HPLC)
生物活性 for CDDO Im
CDDO Im is an Nrf2 signaling activator; increases Nrf2 protein expression and enhances Nrf2-dependent cytoprotective gene expression. CDDO Im inhibits cell growth and induces apoptosis of pancreatic cancer cells in vitro. Also reduces acetaminophen-induced liver injury in mice.
化合物库 for CDDO Im
CDDO Im is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for CDDO Im
| 分子量 | 541.72 |
| 公式 | C34H43N3O3 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 443104-02-7 |
| PubChem ID | 9958995 |
| InChI Key | ITFBYYCNYVFPKD-FMIDTUQUSA-N |
| Smiles | O=C1C(C#N)=C[C@@]2(C)[C@](CC[C@]([C@@]4(C)[C@]([H])3[C@@]5([H])[C@@](CCC(C)(C)C5)([C@](N6C=NC=C6)=O)CC4)(C)C2=CC3=O)([H])C(C)1C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for CDDO Im
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 54.17 | 100 |
制备储备液 for CDDO Im
以下数据基于产品分子量 541.72。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.85 mL | 9.23 mL | 18.46 mL |
| 5 mM | 0.37 mL | 1.85 mL | 3.69 mL |
| 10 mM | 0.18 mL | 0.92 mL | 1.85 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.37 mL |
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产品说明书 for CDDO Im
参考文献 for CDDO Im
参考文献是支持产品生物活性的出版物。
Reisman et al (2009) CDDO-Im protects from acetaminophen hepatotoxicity through induction of Nrf2-dependent genes. Toxicol.Appl.Pharmacol. 236 109 PMID: 19371629
Samudio et al (2005) 2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer. J.Biol.Chem. 280 36273 PMID: 16118208
Aleksunes et al (2010) Transcriptional regulation of renal cytoprotective genes by Nrf2 and its potential use as a therapeutic target to mitigate cisplatin-induced nephrotoxicity. J.Pharmacol.Exp.Ther. 335 2 PMID: 20605904
If you know of a relevant reference for CDDO Im, please let us know.
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关键词: CDDO Im, CDDO Im supplier, CDDOIm, Nrf2, activators, NFE2L2, erythroid-derived, nuclear, factor, 4737, Tocris Bioscience
4 篇 CDDO Im 的引用文献
引用文献是使用了 Tocris 产品的出版物。 CDDO Im 的部分引用包括：
Thomas W et al (2021) Genetic or pharmacologic Nrf2 activation increases proteinuria in chronic kidney disease in mice. Kidney Int 99 102-116 PMID: 32818518
Jörn et al (2018) Nrf2-Mediated Fibroblast Reprogramming Drives Cellular Senescence by Targeting the Matrisome. Dev Cell 46 145-161.e10 PMID: 30016619
Chartoumpekis et al (2018) Nrf2 deletion from adipocytes, but not hepatocytes, potentiates systemic metabolic dysfunction after long-term high-fat diet-induced obesity in mice. Am J Physiol Endocrinol Metab 315 E180 PMID: 29486138
Kyung-Hyun et al (2020) NRF2 Is an Upstream Regulator of MYC-Mediated Osteoclastogenesis and Pathological Bone Erosion. Cells 9 PMID: 32967239
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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