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CDDO-Me

Cat. No. 6646 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6646 has been discontinued.

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说明： Nrf2 pathway activator; also NF-κB pathway inhibitor; inhibits IKKβ
化学名： 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid methyl ester
说明书
引用文献
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文献 (2)
生物活性 技术数据 说明书 参考文献

生物活性 for CDDO-Me

CDDO-Me is a Nrf2 pathway activator. Induces expression of Nrf-2 regulated, cytoprotective genes in vivo. Also blocks the NF-κB pathway by direct inhibition of IKKβ. Inhibits production of a wide range of inflammatory mediators in vitro.

技术数据 for CDDO-Me

分子量 505.69
公式 C32H43NO4
储存 Store at -20°C
CAS Number 218600-53-4
PubChem ID 400769
InChI Key WPTTVJLTNAWYAO-KPOXMGGZSA-N
Smiles [H][C@@]12CC(C)(CC[C@]1(C(OC)=O)CC[C@@]3([C@@]2(C(C=C4[C@]3(CC[C@]5(C(C)(C(C(C#N)=C[C@]45C)=O)C)[H])C)=O)[H])C)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for CDDO-Me

参考文献是支持产品生物活性的出版物。

Ahmad et al (2006) Triterpenoid CDDO-Me blocks the NF-κB pathway by direct inhibition of IKKβ on Cys-179. J.Biol.Chem. 281 35764 PMID: 16998237

Yates et al (2007) Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes. Mol.Cancer Ther. 6 154 PMID: 17237276

Liby & Sporn (2012) Synthetic oleanane triterpenoids: multifunctional drugs with a broad range of applications for prevention and treatment of chronic disease. Pharmacol.Rev. 64 972 PMID: 22966038

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关键词: CDDO-Me, CDDO-Me supplier, CDDO, methyl, ester, bardoxolone, Nrf2, activators, activates, NF-kappaB, inhibitors, inhibits, IKKbeta, IkappaB, NF-kB/IkB, IkB, Kinase, 6646, Tocris Bioscience

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