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Submit ReviewCDN 1163
说明： SERCA2 allosteric activator
化学名： 4-(1-Methylethoxy)-N-(2-methyl-8-quinolinyl)benzamide
纯度： ≥98% (HPLC)
生物活性 for CDN 1163
CDN 1163 is a SERCA2 allosteric activator. Increases Ca2+-ATPase activity and Ca2+ uptake by ER microsomes from obese mice. Rescues HEK cells from ER stress-induced cell death. Reduces fasting glucose levels and adipose tissue weight, and increases energy expenditure in ob/ob mice. Also improves glucose tolerance and reverses hepatic steatosis in ob/ob mice. Neuroprotective, improves memory and cognition in a mouse Alzheimer's disease model and reduces dyskinesia in rat model of Parkinson's disease. Orally bioavailable.
化合物库 for CDN 1163
CDN 1163 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for CDN 1163
| 分子量 | 320.38 |
| 公式 | C20H20N2O2 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 892711-75-0 |
| PubChem ID | 16016585 |
| InChI Key | GVGVYDCVFBGALZ-UHFFFAOYSA-N |
| Smiles | CC1=NC2=C(NC(C3=CC=C(OC(C)C)C=C3)=O)C=CC=C2C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for CDN 1163
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 32.04 | 100 | |
| ethanol | 32.04 | 100 |
制备储备液 for CDN 1163
以下数据基于产品分子量 320.38。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.12 mL | 15.61 mL | 31.21 mL |
| 5 mM | 0.62 mL | 3.12 mL | 6.24 mL |
| 10 mM | 0.31 mL | 1.56 mL | 3.12 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
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产品说明书 for CDN 1163
参考文献 for CDN 1163
参考文献是支持产品生物活性的出版物。
Kang et al (2016) Small molecular allosteric activator of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) attenuates diabetes and metabolic disorders. J.Biol.Chem. 291 5185 PMID: 26702054
Krajnak and Dahl et al (2018) A new target for Alzheimer's disease: A small molecule SERCA activator is neuroprotective in vitro and improves memory and cognition in APP/PS1 mice. Bioorg.Med.Chem.Lett. 28 1591 PMID: 29602679
Dahl (2017) A new target for Parkinson's disease: small molecule SERCA activator CDN1163 ameliorates dyskinesia in 6-OHDA-lesioned rats. Bioorg.Med.Chem.Lett. 25 53 PMID: 27776889
If you know of a relevant reference for CDN 1163, please let us know.
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关键词: CDN 1163, CDN 1163 supplier, CDN1163, allosteric, activators, sarco/endoplasmic, reticulum, Ca2+-ATPase, activates, ER, stress, SERCA2b, type, II, diabetes, T2D, Other, stress/UPR, 5869, Tocris Bioscience
1 篇 CDN 1163 的引用文献
引用文献是使用了 Tocris 产品的出版物。 CDN 1163 的部分引用包括：
Ferdek et al (2017) BH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca2+-like peptides. Cell.Death.Dis. 8 PMID: 28252652
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