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Submit ReviewCercosporamide
说明： Potent Mnk2 inhibitor
化学名： (9aS)-8-Acetyl-9,9a-dihydro-1,3,7-trihydroxy-9a-methyl-9-oxo-4-dibenzofurancaboxamide
纯度： ≥96% (HPLC)
生物活性 for Cercosporamide
Cercosporamide is a potent inhibitor of MAP-kinase interacting kinase-2 (Mnk2) and JAK3 (IC50 values are 11, 31 and 116 nM for Mnk2, JAK3 and Mnk1 respectively). Blocks eIF4E phosphorylation; exhibits antiproliferative and proapoptotic activity in cancer cells in vitro. Also inhibits Pkc1. Orally bioavailable.
技术数据 for Cercosporamide
| 分子量 | 331.28 |
| 公式 | C16H13NO7 |
| 储存 | Store at -20°C |
| 纯度 | ≥96% (HPLC) |
| CAS Number | 131436-22-1 |
| PubChem ID | 131379 |
| InChI Key | GEWLYFZWVLXQME-MRXNPFEDSA-N |
| Smiles | OC1=CC(O)=C(C(N)=O)C3=C1[C@@]2(C)C(O3)=CC(O)=C(C(C)=O)C2=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Cercosporamide
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 3.31 | 10 |
制备储备液 for Cercosporamide
以下数据基于产品分子量 331.28。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 30.19 mL | 150.93 mL | 301.86 mL |
| 0.5 mM | 6.04 mL | 30.19 mL | 60.37 mL |
| 1 mM | 3.02 mL | 15.09 mL | 30.19 mL |
| 5 mM | 0.6 mL | 3.02 mL | 6.04 mL |
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产品说明书 for Cercosporamide
参考文献 for Cercosporamide
参考文献是支持产品生物活性的出版物。
Konicek et al (2011) Therapeutic inhibition of MAP kinase interacting kinase blocks eukaryotic initiation factor 4E phosphorylation and suppresses outgrowth of experimental lung metastases. Cancer Res. 71 1849 PMID: 21233335
Hou et al (2012) Targeting Mnks for cancer therapy. Oncotarget 3 118 PMID: 22392765
Sussman et al (2004) Discovery of cercosporamide, a known antifungal natural product, as a selective Pkc1 kinase inhibitor through high-throughput screening. Eukaryot.Cell 3 932 PMID: 15302826
If you know of a relevant reference for Cercosporamide, please let us know.
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关键词: Cercosporamide, Cercosporamide supplier, antifungals, Mnk2, MKNK2, MAP-kinase, interacting, kinases, Jak3, inhibitors, inhibits, JAK, Kinase, Mnk, 4500, Tocris Bioscience
1 篇 Cercosporamide 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Cercosporamide 的部分引用包括：
Westergard et al (2019) Repeat-associated non-AUG translation in C9orf72-ALS/FTD is driven by neuronal excitation and stress. EMBO Mol Med 11 PMID: 30617154
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.