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CGI 1746

Cat. No. 6965 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent, reversible BTK inhibitor
化学名： N-[3-[4,5-Dihydro-4-methyl-6-[[4-(4-morpholinylcarbonyl)phenyl]amino]-5-oxo-2-pyrazinyl]-2-methylphenyl]-4-(1,1-dimethylethyl)benzamide
纯度： ≥97%
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for CGI 1746

CGI 1746 is a potent, reversible inhibitor of Bruton's tyrosine kinase (Btk) (IC50 = 1.9 nM). CGI 1746 decreases cell survival in prostate cancer cell lines. In a cell model, CGI 1746 blocks the production of FcγR-induced cytokines IL-1β, TNFα and IL-6 (IC50 values are 36 nM, 47 nM and 353 nM, respectively).

技术数据 for CGI 1746

分子量 579.7
公式 C34H37N5O4
储存 Store at -20°C
纯度 ≥97%
CAS Number 910232-84-7
PubChem ID 24857323
InChI Key JIFCFQDXHMUPGP-UHFFFAOYSA-N
Smiles CN1C=C(N=C(NC2=CC=C(C=C2)C(=O)N2CCOCC2)C1=O)C1=C(C)C(NC(=O)C2=CC=C(C=C2)C(C)(C)C)=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CGI 1746

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
ethanol 11.59 20
DMSO 2.9 5

制备储备液 for CGI 1746

以下数据基于产品分子量 579.7。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 8.63 mL 43.13 mL 86.25 mL
1 mM 1.73 mL 8.63 mL 17.25 mL
2 mM 0.86 mL 4.31 mL 8.63 mL
10 mM 0.17 mL 0.86 mL 1.73 mL

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参考文献 for CGI 1746

参考文献是支持产品生物活性的出版物。

Di Paolo et al (2011) Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis. Nat.Chem.Biol. 7 41 PMID: 21113169

Kokabee et al (2015) Bruton's tyrosine kinase is a potential therapeutic target in prostate cancer. Cancer Biol. Ther. 16 1604 PMID: 26383180

If you know of a relevant reference for CGI 1746, please let us know.

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关键词: CGI 1746, CGI 1746 supplier, CGI1746, potent, reversible, inhibitors, inhibits, brutons, tyrosines, kinases, Btk, cytokines, prostate, cancer, IL1beta, TNFalpha, interleukins, tumour, necrosis, factor, Brutons, Tyrosine, Kinase, (BTK), Cytokines, 6965, Tocris Bioscience

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