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Submit ReviewCHDI 113
说明： Potent HTT pre-RNA splicing modulator
化学名： 5-[(3R)-3-(Cyclopropylamino)-1-pyrrolidinyl]-N-(8-fluoro-2-methylimidazo[1,2-a]pyridin-6-yl)-2-pyrazinecarboxamide
纯度： ≥98% (HPLC)
生物活性 for CHDI 113
CHDI 113 is a potent huntingtin (HTT) pre-mRNA splicing modulator (EC50 = 66 nM). It lowers HTT protein in both human Huntington's disease (HD) stem cells and in the brain of BACHD (bacterial artificial chromosome-mediated transgenic) mouse model. CHDI 113 is brain penetrant and orally bioavailable.
许可信息
Sold under license from CHDI Foundation
技术数据 for CHDI 113
| 分子量 | 395.44 |
| 公式 | C20H22FN7O |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 2743336-70-9 |
| PubChem ID | 166508076 |
| InChI Key | VPWHAEPYJSEFEH-CQSZACIVSA-N |
| Smiles | FC1=CC(NC(C2=NC=C(N3C[C@@H](CC3)NC4CC4)N=C2)=O)=CN5C1=NC(C)=C5 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for CHDI 113
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 39.54 | 100 |
制备储备液 for CHDI 113
以下数据基于产品分子量 395.44。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.53 mL | 12.64 mL | 25.29 mL |
| 5 mM | 0.51 mL | 2.53 mL | 5.06 mL |
| 10 mM | 0.25 mL | 1.26 mL | 2.53 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.51 mL |
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产品说明书 for CHDI 113
参考文献 for CHDI 113
参考文献是支持产品生物活性的出版物。
Liu et al (2023) Identification and optimization of RNA-splicing modulators as Huntingtin protein-lowering agents for the treatment of Huntington's disease. J.Med.Chem. 66 13205 PMID: 37712656
If you know of a relevant reference for CHDI 113, please let us know.
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关键词: CHDI 113, CHDI 113 supplier, CHDI113, Pre-mRNA, splicing, modulator, modulates, brain, penetrant, orally, bioavailable, huntingtons, disease, DNA, RNA, and, Protein, Synthesis, in, vivo, stem, cells, DNA,, Biochemicals, Molecular, Biology, 8063, Tocris Bioscience
1 篇 CHDI 113 的引用文献
引用文献是使用了 Tocris 产品的出版物。 CHDI 113 的部分引用包括：
Liu et al (2024) Identification and optimization of RNA-splicing modulators as Huntingtin protein-lowering agents for the treatment of Huntington's disease. J.Med.Chem. 66 13205 PMID: 37712656
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets
Huntington's Disease Research Product Guide
This product guide provides a background to Huntington's disease research and lists around 100 products for the study of:
- Somatic Instability
- Proteolysis and Inclusion Bodies
- Transcriptional Dysregulation
- Mitochondrial Dysfunction
- Nuclear-Cytoplasmic Transport Interference
- Excitotoxicity
- Stem Cells