Chelerythrine chloride

Cat. No. 1330 17 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Cell-permeable protein kinase C inhibitor

化学名： 1,2-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridinium chloride

纯度： ≥98% (HPLC)

引用文献 (17)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Chelerythrine chloride

Chelerythrine chloride is a cell-permeable inhibitor of protein kinase C (IC₅₀ = 660 nM); competitive with respect to the phosphate acceptor and non-competitive with respect to ATP. Has a wide range of biological activities, including antiplatelet, anti-inflammatory, antibacterial and antitumor effects. Activates MAPK pathways, independent of PKC inhibition. Inhibits binding of Bcl_XL to Bak (IC₅₀ = 1.5 μM) or Bad proteins and stimulates apoptosis.

技术数据 for Chelerythrine chloride

分子量	383.83
公式	C₂₁H₁₈ClNO₄
储存	Desiccate at -20°C
纯度	≥98% (HPLC)
CAS Number	3895-92-9
PubChem ID	72311
InChI Key	WEEFNMFMNMASJY-UHFFFAOYSA-M
Smiles	C[N+](C3=C2C=CC4=C3C=C(OCO5)C5=C4)=CC1=C2C=CC(OC)=C1OC.[Cl-]

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Chelerythrine chloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	3.84	10
	DMSO	3.84	10

制备储备液 for Chelerythrine chloride

以下数据基于产品分子量 383.83。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.1 mM	26.05 mL	130.27 mL	260.53 mL
0.5 mM	5.21 mL	26.05 mL	52.11 mL
1 mM	2.61 mL	13.03 mL	26.05 mL
5 mM	0.52 mL	2.61 mL	5.21 mL

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产品说明书 for Chelerythrine chloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Chelerythrine chloride

参考文献是支持产品生物活性的出版物。

Chan et al (2003) Identification of chelerythrine as an inhibitor of BclXL function. J.Biol.Chem. 278 20453 PMID: 12702731

Herbert et al (1990) Chelerythrine is a potent and specfic inhibitor of protein kinase C. Biochem.Biophys.Res.Commun. 172 993 PMID: 2244923

Lee et al (1998) Angoline and chelerythrine, benzophenanthridine alkaloids that do not inhibit protein kinase C. J.Biol.Chem. 273 19829 PMID: 9677417

Yu et al (2000) Activation of p38 and c-Jun N-terminal kinase pathways and induction of apoptosis by chelerythrine do not require inhibition of protein kinase C. J.Biol.Chem. 275 9612 PMID: 10734112

If you know of a relevant reference for Chelerythrine chloride, please let us know.

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关键词: Chelerythrine chloride, Chelerythrine chloride supplier, Potent, protein, kinase, C, inhibitors, inhibits, PKC, Kinases, Protein, Kinase, 1330, Tocris Bioscience