CHIR 98014

Cat. No. 6695 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Highly potent and selective GSK-3 inhibitor

化学名： N⁶-[2-[[4-(2,4-Dichlorophenyl)-5-(1H-imidazol-1-yl)-2-pyrimidinyl]amino]ethyl]-3-nitro-2,6-pyridinediamine

纯度： ≥98% (HPLC)

文献 (4)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for CHIR 98014

CHIR 98014 is a highly potent and selective GSK-3 inhibitor (IC₅₀ values are 0.58 and 0.65 nM for the β and α isoforms, respectively). Exhibits >500-fold selectivity for GSK-3β over a range of other kinases. Improves insulin sensitivity of muscle strips from diabetic rats in vitro and decreases insulin and glucose levels in the oral glucose tolerance test in vivo. Activates Wnt signaling in human adipose stem cells (hASC) and promotes the production of definitive endoderm. Has been used in protocols to derive epicardial cells from hPSCs.

技术数据 for CHIR 98014

分子量	486.31
公式	C₂₀H₁₇Cl₂N₉O₂
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	252935-94-7
PubChem ID	53396311
InChI Key	MDZCSIDIPDZWKL-UHFFFAOYSA-N
Smiles	NC1=NC(NCCNC2=NC=C(C(C3=C(C=C(C=C3)Cl)Cl)=N2)N4C=CN=C4)=CC=C1[N+]([O-])=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CHIR 98014

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	9.73	20 温和加热

制备储备液 for CHIR 98014

以下数据基于产品分子量 486.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.2 mM	10.28 mL	51.41 mL	102.82 mL
1 mM	2.06 mL	10.28 mL	20.56 mL
2 mM	1.03 mL	5.14 mL	10.28 mL
10 mM	0.21 mL	1.03 mL	2.06 mL

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产品说明书 for CHIR 98014

分析证书/产品说明书

化学品安全技术说明书

参考文献 for CHIR 98014

参考文献是支持产品生物活性的出版物。

Ring et al (2003) Selective glycogen synthase kinase 3 inhibitors potentiate Ins activation of glucose transport and utilization in vitro and in vivo. Diabetes 52 588 PMID: 12606497

Paik and Wu et al (2017) Simply derived epicardial cells. Nat.Biomed.Eng. 1 PMID: 29354320

Huang et al (2017) Activation of Wnt/β-catenin signalling via GSK3 inhibitors direct differentiation of human adipose stem cells into functional hepatocytes. Sci.Rep. 7 40716 PMID: 28094799

If you know of a relevant reference for CHIR 98014, please let us know.

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Pathways for CHIR 98014

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The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.