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CHM 1

Cat. No. 3868 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3868 has been discontinued.

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说明： Potent antitumor agent; inducer of apoptosis
化学名： 6-(2-Fluorophenyl)-1,3-dioxolo[4,5-g]quinolin-8(5H)-one
纯度： ≥99% (HPLC)
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生物活性 技术数据 说明书 参考文献

生物活性 for CHM 1

Inducer of apoptosis; displays potent antitumor ability in human hepatocellular carcinoma. Inhibits tubulin polymerization in vitro and in vivo. Causes cell cycle arrest at G2/M phase by activation of Cdc2 kinase activity. Induces translocation of apoptosis inducing factor (AIF) from the mitochondria to nucleus. Also exhibits vascular targeting activity through upregulation of p53 and induction of death receptor (DR5)-mediated apoptosis in HUVEC cells.

技术数据 for CHM 1

分子量 283.25
公式 C16H10FNO3
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 154554-41-3
PubChem ID 375860
InChI Key ZMYDAPJHGNEFGQ-UHFFFAOYSA-N
Smiles O=C2C=C(C3=CC=CC=C3F)NC1=CC4=C(OCO4)C=C12

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

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关键词: CHM 1, CHM 1 supplier, CHM1, apoptosis, inducer, inhibits, tubulin, polymerization, inhibitors, antitumor, antivascular, cell, cycle, arrest, Apoptosis, Inducers, 3868, Tocris Bioscience

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Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for CHM 1

Apoptosis Signaling Pathway

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.