CHR 2797

Cat. No. 3595 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Aminopeptidase inhibitor

别名： Tosedostat

化学名： α-[[(2R)-2-[(1S)-1-Hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]amino]-benzeneacetic acid cyclopently ester

纯度： ≥98% (HPLC)

引用文献 (3)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for CHR 2797

CHR 2797 is an aminopeptidase inhibitor (IC₅₀ values are 100, 150, 220, > 1000, > 5000, > 10000 and > 30000 nM for LAP, PuSA, aminopeptidase N, aminopeptidase B, PILSAP, LTA₄ hydrolase and MetAP2, respectively). Potently inhibits tumor cell proliferation in a variety of tumor cell lines in vitro and in vivo. Also inhibits neprilysin (IC₅₀ = 900 nM). Exhibits antinociceptive activity and enhances the efficacy of Morphine (Cat. No. 5158) in the hot-plate and tail-flick assays, via an action on the peripheral nervous system.

化合物库 for CHR 2797

CHR 2797 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for CHR 2797

分子量	406.48
公式	C₂₁H₃₀N₂O₆
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	238750-77-1
PubChem ID	15547703
InChI Key	FWFGIHPGRQZWIW-SQNIBIBYSA-N
Smiles	O=C([C@H]([C@]2=CC=CC=C2)NC([C@@H]([C@@H](C(NO)=O)O)CC(C)C)=O)OC1CCCC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CHR 2797

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	40.65	100
	ethanol	20.32	50

制备储备液 for CHR 2797

以下数据基于产品分子量 406.48。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.46 mL	12.3 mL	24.6 mL
5 mM	0.49 mL	2.46 mL	4.92 mL
10 mM	0.25 mL	1.23 mL	2.46 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

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产品说明书 for CHR 2797

分析证书/产品说明书

化学品安全技术说明书

参考文献 for CHR 2797

参考文献是支持产品生物活性的出版物。

Krige et al (2008) CHR-2797: an anitproliferative aminopeptidase inhibitor that leads to amino acid deprivation in human leukemic cells. Cancer Res. 68 6669 PMID: 18701491

Moore et al (2009) Aminopeptidase inhibition as a targeted treatment strategy in myeloma. Mol.Cancer Ther. 8 762 PMID: 19372548

Singh et al (2019) Discovery of anticancer clinical candidate, Tosedostat, as an analgesic agent. ACS Chem.Neurosci. 10 4007 PMID: 31415151

If you know of a relevant reference for CHR 2797, please let us know.

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关键词: CHR 2797, CHR 2797 supplier, aminopeptidases, inhibitors, inhibits, proteases, proteinases, CHR2797, neprilysin, neutral, endopeptidase, NEP, Tosedostat, Aminopeptidases, 3595, Tocris Bioscience

3 篇 CHR 2797 的引用文献

引用文献是使用了 Tocris 产品的出版物。 CHR 2797 的部分引用包括：

Yogin et al (2022) Cancer genes disfavoring T cell immunity identified via integrated systems approach. Cell Rep 40 111153 PMID: 35926468

Justin R et al (2022) M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome. Nat Chem Biol 18 565-574 PMID: 35165443

Orth-He et al (2023) Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation. Cell Rep 42 111965 PMID: 36649711

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