Cladribine

Cat. No. 5292 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Deoxyadenosine analog; pro-apoptotic

别名： 2-Chloro-2'-deoxyadenosine

化学名： (2R,3S,5R)-5-(6-Amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxalan-3-ol

纯度： ≥99% (HPLC)

引用文献 (1)

文献 (1)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Cladribine

Cladribine is an adenosine deaminase (ADA)-resistant analog of deoxyadenosine. Exhibits anti-leukemic activity; Inhibits cell growth of lymphoid and myeloid neoplasm (IC₅₀ = 20 - 87 nM). Pro-apoptotic; induces DNA double-strand breaks. Also inhibits ribonuclease reductase (IC₅₀ = 0.11 - 0.28 μM). Displays activity in vitro and in vivo. Orally bioavailable.

技术数据 for Cladribine

分子量	285.69
公式	C₁₀H₁₂ClN₅O₃
储存	Store at +4°C
纯度	≥99% (HPLC)
CAS Number	4291-63-8
PubChem ID	20279
InChI Key	PTOAARAWEBMLNO-KVQBGUIXSA-N
Smiles	OC[C@H]1O[C@@H](N2C=NC3=C2N=C(Cl)N=C3N)C[C@@H]1O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Cladribine

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	28.57	100

制备储备液 for Cladribine

以下数据基于产品分子量 285.69。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.5 mL	17.5 mL	35 mL
5 mM	0.7 mL	3.5 mL	7 mL
10 mM	0.35 mL	1.75 mL	3.5 mL
50 mM	0.07 mL	0.35 mL	0.7 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

产品说明书 for Cladribine

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Cladribine

参考文献是支持产品生物活性的出版物。

Bryson et al (1993) Cladribine. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in haematological malignancies. Drugs 46 872 PMID: 7507037

Robak et al (2006) Older and new formulations of cladr. Pharmacology and clinical efficacy in hematological malignancies. Recent Pat. Anticancer Drug Discov. 1 23 PMID: 18221024

Seto et al (1985) Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytes. J. Clin. Invest. 75 377 PMID: 2579098

If you know of a relevant reference for Cladribine, please let us know.

按标靶查看相关产品

关键词: Cladribine, Cladribine supplier, leukemia, adenosine, deaminase, antileukemic, proapoptotic, ribonuclease, reductase, deoxyadenosine, analogue, analog, 2-Chloro-2-deoxyadenosine, antimetabolites, 2-Chloro-2'-deoxyadenosine, Apoptosis, Inducers, Ribonucleotide, Reductase, 5292, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Cladribine, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

1 篇 Cladribine 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Cladribine 的部分引用包括：

Weiterer et al (2015) Galactomannan and Zymosan Block the Epinephrine-Induced Particle Transport in Tracheal Epithelium. J Biomed Sci 10 e0143163 PMID: 26571499

您是否知道使用了 Tocris Cladribine 的优秀论文？请告知我们.

Cladribine 的评论

目前没有该产品的评论。 Be the first to review Cladribine and earn rewards!

Have you used Cladribine?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for Cladribine

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.