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Submit ReviewCompound 401
说明： Selective DNA-PK and mTOR inhibitor
化学名： 2-(4-Morpholinyl)-4H-pyrimido[2,1-a]isoquinolin-4-one
纯度： ≥99% (HPLC)
生物活性 for Compound 401
Compound 401 is a reversible and selective inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR) (IC50 values are 0.28 and 5.3 μM respectively). Displays little affinity for other commonly studied kinases including PI 3-K, ATM and ATR (IC50 values are all > 100 μM). Induces apoptosis in vitro.
技术数据 for Compound 401
| 分子量 | 281.31 |
| 公式 | C16H15N3O2 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 168425-64-7 |
| PubChem ID | 10039361 |
| InChI Key | BVRDQVRQVGRNHG-UHFFFAOYSA-N |
| Smiles | O=C3N2C=CC1=CC=CC=C1C2=NC(N4CCOCC4)=C3 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Compound 401
参考文献 for Compound 401
参考文献是支持产品生物活性的出版物。
Griffen et al (2005) Selective benzopyranone and pyrimido[2,1-α]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies and radiosensitization of a human tumor cell line in vitro. J.Med.Chem. 48 569 PMID: 15658870
Ballo et al (2007) Inhibition of mammalian target of rapamycin signaling by 2-(morpholin-1-yl)oyrimido[2,1-α]isoquinolin-4-one. J.Biol.Chem. 282 24463 PMID: 17562705
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关键词: Compound 401, Compound 401 supplier, Selective, DNA-PK, mTOR, inhibitors, inhibits, Checkpoint, Control, Kinases, DNA-Dependent, Protein, Kinase, PI3K, Phosphoinositide, PI, 3-kinase, Akt, Signaling, Signalling, Mammalian, Target, Rapamycin, FRAP, Compound401, DNA-dependent, 3271, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.