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CST 530

Cat. No. 8065 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Monovalent IAP antagonist
化学名： (2S,4S)-1-((S)-2-Cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)-4-phenoxy-N-((R)-1,2,3,4-tetrahydronaphthalen-1-yl)pyrrolidine-2-carboxamide
纯度： ≥97% (HPLC)
说明书
引用文献
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通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for CST 530

CST 530 is a monovalent IAP antagonist. Induces potent cIAP1 autodegradation and mild cIAP2 depletion. CST 530 reduces cell viability in a variety of cancer cell lines including SUDHL6, MOLM13 and HEL (IC50 values are 170 nM, 420 nM and 450 nM respectively).

技术数据 for CST 530

分子量 560.74
公式 C33H44N4O4
储存 Store at -20°C
纯度 ≥97% (HPLC)
CAS Number 847137-53-5
InChI Key GUOVHJVNYPRNQS-SHUILBLCSA-N
Smiles CN[C@@H](C)C(N[C@@H](C1CCCCC1)C(N2[C@@H](C[C@@H](C2)OC3=CC=CC=C3)C(N[C@H]4C5=CC=CC=C5CCC4)=O)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CST 530

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 56.07 100

制备储备液 for CST 530

以下数据基于产品分子量 560.74。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.78 mL 8.92 mL 17.83 mL
5 mM 0.36 mL 1.78 mL 3.57 mL
10 mM 0.18 mL 0.89 mL 1.78 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

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参考文献 for CST 530

参考文献是支持产品生物活性的出版物。

Ng et al (2023) Heterobifunctional ligase recruiters enable pan-degradation of inhibitor of apoptosis proteins. J.Med.Chem. 66 4703 PMID: 36996313

If you know of a relevant reference for CST 530, please let us know.

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关键词: CST 530, CST 530 supplier, CST530, inhibitor, of, apoptosis, IAP, antagonist, autodegradation, cell, viability, cIAP1, cIAP2, potent, Inhibitor, Apoptosis, (IAP), Ubiquitin, E3, Ligases, 8065, Tocris Bioscience

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Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for CST 530

Apoptosis Signaling Pathway

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.