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CTA 056

Cat. No. 4726 1 次引用 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： ITK inhibitor
化学名： 1,5-Dihydro-7-(phenylmethyl)-1-[3-(1-piperidinyl)propyl]-2-[4-(4-pyridinyl)phenyl]-6H-imidazo[4,5-g]quinoxalin-6-one
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for CTA 056

CTA 056 is an interleukin-2-inducible T-cell kinase (ITK) inhibitor (IC50 values are 0.1, 0.4 and 5 μM for ITK, BTK and ETK, respectively). Inhibits growth of cancer cells expressing ITK, including MOLT-4 and Jurkat cells in vitro. Induces apoptosis in Jurkat cells. Inhibits MOLT-4 xenograft tumor growth in mice.

技术数据 for CTA 056

分子量 554.68
公式 C35H34N6O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1265822-30-7
PubChem ID 49870925
InChI Key BSSBAJKNZOHHCA-UHFFFAOYSA-N
Smiles O=C2C(CC7=CC=CC=C7)=NC1=CC3=C(N=C(C5=CC=C(C6=CC=NC=C6)C=C5)N3CCCN4CCCCC4)C=C1N2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CTA 056

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 5.55 10 温和加热

制备储备液 for CTA 056

以下数据基于产品分子量 554.68。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.1 mM 18.03 mL 90.14 mL 180.28 mL
0.5 mM 3.61 mL 18.03 mL 36.06 mL
1 mM 1.8 mL 9.01 mL 18.03 mL
5 mM 0.36 mL 1.8 mL 3.61 mL

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参考文献 for CTA 056

参考文献是支持产品生物活性的出版物。

Guo et al (2012) Molecular characteristics of CTA056, a novel interleukin-2-inducible T-cell kinase inhibitor that selectively targets malignant T cells and modulates oncomirs. Mol.Pharmacol. 82 938 PMID: 22899868

If you know of a relevant reference for CTA 056, please let us know.

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关键词: CTA 056, CTA 056 supplier, CTA056, cancer, apoptosis, interleukin, 2, inducible, T-cell, kinase, Itk, inhibitors, inhibits, induces, inducers, ITK, 4726, Tocris Bioscience

1 篇 CTA 056 的引用文献

引用文献是使用了 Tocris 产品的出版物。 CTA 056 的部分引用包括：

Mues et al (2019) High-Complexity shRNA Libraries and PI3 Kinase Inhibition in Cancer: High-Fidelity Synthetic Lethality Predictions. Cell Rep 27 631 PMID: 30970263

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CTA 056 的评论

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T-ALL Network and Pharmacological Validation of Synthetic Lethal Screen.
By Anonymous on 03/26/2020
分析类型： In Vitro
种属： Human
细胞系/组织： T cell line

10uM

PMID: 30970263
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