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Submit ReviewCurcumin
说明： Antitumor, anti-inflammatory and antioxidant
别名： Diferuloylmethane
化学名： (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione
生物活性 for Curcumin
Curcumin is an antitumor, anti-inflammatory and antioxidant agent. Downregulates expression of reactive-oxygen-generating enzymes (cyclooxygenase, lipoxygenase, iNOS), TNFα, IL-1, IL-6, PKC, EGFR, NF-κB, IκB kinase and more. Upregulates expression of PPARγ, p53, Nrf2. Also displays antimicrobial, antidiabetic neuro- and cardioprotective properties in vivo.
技术数据 for Curcumin
| 分子量 | 368.38 |
| 公式 | C21H20O6 |
| 储存 | Store at -20°C |
| CAS Number | 458-37-7 |
| PubChem ID | 969516 |
| InChI Key | VFLDPWHFBUODDF-FCXRPNKRSA-N |
| Smiles | O=C(CC(/C=C/C2=CC=C(O)C(OC)=C2)=O)/C=C/C1=CC(OC)=C(O)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Curcumin
参考文献 for Curcumin
参考文献是支持产品生物活性的出版物。
Kuttan et al (2007) Antitumour, anti-invasion, and antimetastatic effects of curcumin. Adv.Exp.Med.Biol. 595 173 PMID: 17569210
Cole et al (2007) Neuroprotective effects of curcumin. Adv.Exp.Med.Biol. 595 197 PMID: 17569212
Lin (2007) Molecular targets of curcumin. Adv.Exp.Med.Biol. 595 227 PMID: 17569214
Miriyala et al (2007) Cardioprotective effects of curcumin. Adv.Exp.Med.Biol. 595 359 PMID: 17569220
Aggarwal and Sung (2009) Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets. TiPS 30 85 PMID: 19110321
关键词: Curcumin, Curcumin supplier, Antitumor, anti-inflammatory, antioxidant, Apoptosis, Inducer, nrf2, Diferuloylmethane, Inducers, Antioxidants, Nrf2, 2841, Tocris Bioscience
5 篇 Curcumin 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Curcumin 的部分引用包括：
Boija et al (2017) CBP Regulates Recruitment and Release of Promoter-Proximal RNA Polymerase II. Mol Cell 68 491 PMID: 29056321
Chang et al (2015) Protection against β-amyloid-induced synaptic and memory impairments via altering β-amyloid assembly by bis(heptyl)-cognitin. Sci Rep 5 10256 PMID: 26194093
Chen et al (2012) Curcumin inhibits HCV replication by induction of heme oxygenase-1 and suppression of AKT. Int J Mol Med 30 1021 PMID: 22922731
Han et al (2012) Analgesic effects of intrathecal curcumin in the rat formalin test. Korean J Pain 25 43252 PMID: 22259709
Efthymiou et al (2015) Rescue of an in vitro neuron phenotype identified in Niemann-Pick disease, type C1 induced pluripotent stem cell-derived neurons by modulating the WNT pathway and calcium signaling. J Neurosci 4 230 PMID: 25637190
Curcumin 的评论
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.
Pathways for Curcumin
