Cycloheximide

Name: Cycloheximide
Brand: Tocris Bioscience
SKU: 0970
Rating: 5 (3 reviews)

Cat. No. 0970 18 篇引用文献 3 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Inhibitor of protein synthesis

化学名： 4-[2-(3,5-Dimethyl-2-oxo-cyclohexyl)-2-hydroxyethyl]-2,6-piperidinedione

纯度： ≥97% (HPLC)

说明书

引用文献 (18)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Cycloheximide

Cycloheximide is a selective inhibitor of eukaryotic (over prokaryotic) protein synthesis, blocking tRNA binding and release from ribosomes. Induces apoptosis in a variety of transformed and normal cell lines, including T cells. Competitively inhibits the PPIase hFKBP12 (K_i = 3.4 μM). Also inhibits ferroptosis. Antifungal antibiotic. Exhibits anti-MERS-CoV activity in Vero cells in vitro (IC₅₀ = 0.16 μM).

技术数据 for Cycloheximide

分子量	281.35
公式	C₁₅H₂₃NO₄
储存	Desiccate at RT
纯度	≥97% (HPLC)
CAS Number	66-81-9
PubChem ID	6197
InChI Key	YPHMISFOHDHNIV-FSZOTQKASA-N
Smiles	O=C(N1)CC(C[C@@H](O)[C@]2([H])C[C@@H](C)C[C@H](C)C2=O)CC1=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Cycloheximide

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	ethanol	14.07	50
	water	7.03	25

制备储备液 for Cycloheximide

以下数据基于产品分子量 281.35。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	7.11 mL	35.54 mL	71.09 mL
2.5 mM	1.42 mL	7.11 mL	14.22 mL
5 mM	0.71 mL	3.55 mL	7.11 mL
25 mM	0.14 mL	0.71 mL	1.42 mL

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产品说明书 for Cycloheximide

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Cycloheximide

参考文献是支持产品生物活性的出版物。

Christner et al (1999) Synthesis and cytotoxic evaluation of cycloheximide derivatives as potential inhibitors of FKBP12 with neuroregenerative properties. J.Med.Chem. 42 3615 PMID: 10479292

Obrig et al (1971) The mechanism by which cycloheximide and related glutarimide antibiotics inhibit peptide synthesis on reticulocyte ribosomes. J.Biol.Chem. 246 174 PMID: 5541758

Tang et al (1999) Cycloheximide-induced T-cell death is mediated by a Fas-associated death domain-dependent mechanism. J.Biol.Chem. 274 7245 PMID: 10066786

Xie et al (2016) Ferroptosis: process and function. Cell.Death.Differ. 23 369 PMID: 26794443

Ko et al (2021) Screening of FDA-approved drugs using a MERS-CoV clinical isolate from South Korea identifies potential therapeutic options for COVID-19. Viruses 13 PMID: 33918958

Sawicki and Sawicki et al (1986) Coronavirus minus-strand RNA synthesis and effect of cycloheximide on coronavirus RNA synthesis. J.Virol. 57 328 PMID: 2867230

If you know of a relevant reference for Cycloheximide, please let us know.

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⚠ WARNING: This product can expose you to chemicals including Cycloheximide, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov