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Cyclophosphamide

Cat. No. 4091 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Alkylating agent; chemotherapeutic
化学名： 2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
纯度： ≥99% (HPLC)
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引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Cyclophosphamide

Cyclophosphamide is a nitrogen mustard alkylating agent and prodrug. Phosphoramide mustard (active metabolite) forms DNA cross-links leading to cell death. Inhibits aldehyde dehydrogenase 1 (ALDH1) through its degradation product acrolein. Chemotherapeutic for the treatment of breast cancer; regulates Bax and Bcl-2 expression when administered with etoposide (Cat. No. 1226) in breast cancer cell lines.

技术数据 for Cyclophosphamide

分子量 261.09
公式 C7H15Cl2N2O2P
储存 Store at -20°C
纯度 ≥99% (HPLC)
CAS Number 50-18-0
PubChem ID 2907
InChI Key CMSMOCZEIVJLDB-UHFFFAOYSA-N
Smiles O=P1(N(CCCl)CCCl)OCCCN1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Cyclophosphamide

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 26.11 100
DMSO 26.11 100

制备储备液 for Cyclophosphamide

以下数据基于产品分子量 261.09。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.83 mL 19.15 mL 38.3 mL
5 mM 0.77 mL 3.83 mL 7.66 mL
10 mM 0.38 mL 1.92 mL 3.83 mL
50 mM 0.08 mL 0.38 mL 0.77 mL

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产品说明书 for Cyclophosphamide

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for Cyclophosphamide

参考文献是支持产品生物活性的出版物。

Gibson et al (1999) Regulation of BAX and BCL-2 expression in breast cancer cells by chemotherapy. Breast Cancer Research and Treatment 55 107 PMID: 10481938

Hengstler et al (1992) DNA strand breaks and DNA cross-links in peripheral mononuclear blood cells of ovarian cancer patients during chemotherapy with cyclophosphamide/carboplatin. Cancer Res. 15 52

Ren et al (1999) Inhibition of human aldehyde dehydrogenase 1 by the 4-hydroxycyclophosphamide degradation product acrolein. Drug Metab.Disp. 27 133

If you know of a relevant reference for Cyclophosphamide, please let us know.

按标靶查看相关产品

关键词: Cyclophosphamide, Cyclophosphamide supplier, chemotherapeutics, cross-links, alkylates, DNA, cytotoxic, inhibits, inhibitors, aldehyde, dehydrogenase, 1, ALDH1, Apoptosis, Inducers, DNA,, RNA, and, Protein, Synthesis, 4091, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Cyclophosphamide (anhydrous), which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov

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该领域的文献

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Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for Cyclophosphamide

Apoptosis Signaling Pathway

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.