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Cyclosporin H

Cat. No. 6982 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Enhances lentiviral transduction
化学名： 5-(N-Methyl-D-valine)cyclosporin A
纯度： ≥97% (HPLC)
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Cyclosporin H

Cyclosporin H is a viral transduction enhancer. Increases lentiviral transduction up to 10-fold in human cord blood-derived hematopoietic stem and progenitor cells (HSPCs). Displays an additive effect when combined with rapamycin (Cat. No. 1292) or prostaglandin E2 (Cat. No. 2296). Lacks immunosuppressant activity of cyclosporin A (Cat. No. 1101).

技术数据 for Cyclosporin H

分子量 1202.64
公式 C62H111N11O12
储存 Store at -20°C
纯度 ≥97% (HPLC)
CAS Number 83602-39-5
PubChem ID 6476564
InChI Key PMATZTZNYRCHOR-JLPRAAIDSA-N
Smiles [H][C@]1(NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C(=O)[C@H](CC)NC(=O)[C@]([H])([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@@]([H])(C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@]([H])(CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C1=O)C(C)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Cyclosporin H

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 120.26 100
ethanol 60.13 50

制备储备液 for Cyclosporin H

以下数据基于产品分子量 1202.64。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 0.83 mL 4.16 mL 8.32 mL
5 mM 0.17 mL 0.83 mL 1.66 mL
10 mM 0.08 mL 0.42 mL 0.83 mL
50 mM 0.02 mL 0.08 mL 0.17 mL

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产品说明书 for Cyclosporin H

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for Cyclosporin H

参考文献是支持产品生物活性的出版物。

Petrillo et al (2018) Cyclosporine H overcomes innate immune restrictions to improve lentiviral transduction and gene editing in human hematopoietic stem cells. Cell Stem Cell. 23 820 PMID: 30416070

If you know of a relevant reference for Cyclosporin H, please let us know.

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关键词: Cyclosporin H, Cyclosporin H supplier, viral, transduction, enhancers, gene, delivery, enhances, Viral, Transduction, Enhancers, 6982, Tocris Bioscience

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Stem Cell Research Product Guide

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