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Daptomycin

Cat. No. 3917 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Antibiotic; inhibits protein, DNA and RNA synthesis in gram-positive bacteria
别名： LY 146032
化学名： N-(1-Oxodecyl)-L-tryptophyl-D-asparaginyl-L-α-aspartyl-L-threonylglycyl-L-ornithinyl-L-α-aspartyl-D-alanyl-L-α-aspartylglycyl-D-seryl-(3R)-3-methyl-L-α-glutamyl-α,2-diamino-γ-oxo-benzene butanoic acid (13-4) lactone
纯度： ≥95% (HPLC)
说明书
引用文献 (1)
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Daptomycin

Daptomycin is a lipopeptide, calcium-dependent antibiotic. Exhibits potent bacteriocidal activity against most gram-positive bacteria in vitro and in vivo, including antibiotic-resistant strains such as MRSA and VRE. Disrupts plasma membrane function; activity results in membrane depolarization leading to inhibition of protein, DNA and RNA synthesis.

技术数据 for Daptomycin

分子量 1620.67
公式 C72H101N17O26
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 103060-53-3
PubChem ID 16129629
InChI Key DOAKLVKFURWEDJ-OFNKPWESSA-N
Smiles O=C(N[C@@H](CCCN)C(N[C@@H](CC(O)=O)C(N[C@H](C)C4=O)=O)=O)CN[C@]([C@H]([C@H](OC([C@@H](NC([C@@H](NC([C@@H](CO)NC(CNC([C@@H](N4)CC(O)=O)=O)=O)=O)[C@@H](C)CC(O)=O)=O)CC(C3=CC=CC=C3N)=O)=O)C)NC([C@H](CC(O)=O)NC([C@@H](CC(N)=O)NC([C@H](CC1=CNC2=C1C=CC=C2)NC(CCCCCCCCC)=O)=O)=O)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Daptomycin

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 162.07 100
water 32.41 20

制备储备液 for Daptomycin

以下数据基于产品分子量 1620.67。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 0.62 mL 3.09 mL 6.17 mL
5 mM 0.12 mL 0.62 mL 1.23 mL
10 mM 0.06 mL 0.31 mL 0.62 mL
50 mM 0.01 mL 0.06 mL 0.12 mL

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产品说明书 for Daptomycin

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Daptomycin

参考文献是支持产品生物活性的出版物。

Tally and DeBruin (2000) Development of dapto. for gram-positive infections. J.Antimicrob Chemother. 46 523 PMID: 11020247

Jung et al (2004) Structural transitions as determinants of the action of the calcium-dependent antibiotic dapto. Chem.Biol. 11 949 PMID: 15271353

Steenbergen et al (2005) Daptomycin: a lipopeptide antibiotic for the treatment of serious gram-positive infections. J.Antimicrob Chemother. 55 283 PMID: 15705644

Robbel and Marahiel (2010) Daptomycin, a bacterial lipopeptide synthesized by a non-ribosomal machinery. J.Biol.Chem. 285 27501 PMID: 20522545

If you know of a relevant reference for Daptomycin, please let us know.

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关键词: Daptomycin, Daptomycin supplier, antibiotics, lipopeptide, Gram-positive, bacteria, infection, bacteriocidal, inhibitors, inhibits, protein, DNA, synthesis, LY146032, LY, 146032, antibacterial, DNA,, RNA, and, Protein, Synthesis, Antibiotics, 3917, Tocris Bioscience

1 篇 Daptomycin 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Daptomycin 的部分引用包括：

Jane C et al (2021) Colistin kills bacteria by targeting lipopolysaccharide in the cytoplasmic membrane. Elife 10 PMID: 33821795

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