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说明： Anticancer and antiviral agent; chemopreventive and pro-apoptotic
化学名： (7aS,13aS)-13,13a-Dihydro-9,10-dimethoxy-3,3-dimethyl-3H-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7(7aH)-one
纯度： ≥97% (HPLC)
生物活性 for Deguelin
Anticancer and antiviral agent; chemopreventive and pro-apoptotic. Inhibits phorbol ester-induced ornithine decarboxylase and NADH:ubiquinone oxidoreductase activities (IC50 values are 11 and 6.9 nM respectively). Inhibits PI 3-kinase and reduces pAkt levels in pre-malignant and malignant human bronchial epithelial cells. Active in vivo.
技术数据 for Deguelin
| 分子量 | 394.42 |
| 公式 | C23H22O6 |
| 储存 | Store at -20°C |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 522-17-8 |
| PubChem ID | 107935 |
| InChI Key | ORDAZKGHSNRHTD-UXHICEINSA-N |
| Smiles | O=C(C(C=CC5=C4C=CC(C)(C)O5)=C4O3)[C@@]([C@@]3([H])CO2)([H])C1=C2C=C(OC)C(OC)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Deguelin
参考文献 for Deguelin
参考文献是支持产品生物活性的出版物。
Chun et al (2003) Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells. J.Natl.Cancer Inst. 95 291 PMID: 12591985
Fang and Casida (1998) Anticancer action of cube insecticide: correlation for rotenoid constituents between inhibition of NADH:ubiquinone oxidoreductase and induced ornithine decarboxylase activities. Proc.Natl.Acad.Sci.U.S.A. 95 3380 PMID: 9520374
Takatsuki et al (1969) Antiviral and antitumor antibiotics. XX. Effects of rotenone, deguelin, and related compounds on animal and plant viruses. Appl.Microbiol. 18 660 PMID: 4312925
Udeani et al (1997) Cancer chemopreventive activity mediated by deguelin, a naturally occurring rotenoid. Cancer Res. 57 3424 PMID: 9270008
关键词: Deguelin, Deguelin supplier, Anticancer, antiviral, agent, chemopreventive, proapoptotic, Apoptosis, Inducer, Inducers, Non-selective, Antivirals, 1770, Tocris Bioscience
2 篇 Deguelin 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Deguelin 的部分引用包括：
Hafeez et al (2016) BAD, a Proapoptotic Protein, Escapes ERK/RSK Phosphorylation in Deguelin and siRNA-Treated HeLa Cells. J Neurosci 11 e0145780 PMID: 26745145
Rebolleda et al (2016) Synergistic Activity of Deguelin and fludar. in Cells from Chronic Lymphocytic Leukemia Patients and in the New Zealand Black Murine Model. PLoS One 11 e0154159 PMID: 27101369
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.
Pathways for Deguelin
