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DMNB

Cat. No. 2088 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2088 has been discontinued.

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说明： DNA-PK inhibitor
化学名： 4,5-Dimethoxy-2-nitrobenzaldehyde
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (2)
生物活性 技术数据 说明书 参考文献

生物活性 for DMNB

Inhibitor of DNA-dependent protein kinase (DNA-PK) (IC50 = 15 μM), an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair in human cells. Displays 100-fold higher potency than its analog vanillin and does not affect PKC activity. Produces lethal effects on cisplatin-treated D5037 cells upon continuous exposure.

技术数据 for DMNB

分子量 211.15
公式 C9H9NO5
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 20357-25-9
PubChem ID 88505
InChI Key YWSPWKXREVSQCA-UHFFFAOYSA-N
Smiles COC1=C(OC)C=C(C(C=O)=C1)[N+]([O-])=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for DMNB

参考文献是支持产品生物活性的出版物。

Durant and Karran (2003) Vanillins - a novel family of DNA-PK inhibitors. Nucleic Acids Res. 31 5501 PMID: 14500812

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关键词: DMNB, DMNB supplier, DNA-dependent, protein, kinases, inhibitors, inhibits, Checkpoint, Control, Kinases, DNA-PK, Protein, Kinase, 2088, Tocris Bioscience

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