DPPI 1c hydrochloride

Cat. No. 2783 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Dipeptidyl peptidase IV (DPP-IV) inhibitor

化学名： 1-[[[(1-Hydroxymethyl)cyclopentyl]amino]acetyl]-2,5-cis-pyrrolidinedicarbonitrile hydrochloride

纯度： ≥98% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for DPPI 1c hydrochloride

DPPI 1c hydrochloride is an inhibitor of dipeptidyl peptidase IV (DPP-IV) (IC₅₀ = 104 nM) that displays selectivity over enzymes with DPP-like activity (IC₅₀ > 30 μM). Increases plasma GLP-1 levels and improves glucose tolerance in diabetic mice following oral glucose challenge.

化合物库 for DPPI 1c hydrochloride

DPPI 1c hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for DPPI 1c hydrochloride

分子量	312.8
公式	C₁₄H₂₀N₄O₂.HCl
储存	Desiccate at RT
纯度	≥98% (HPLC)
CAS Number	866396-70-5
PubChem ID	11381415
InChI Key	RHCWAHDCHQTNBR-IWKKHLOMSA-N
Smiles	O=C(CNC2(CO)CCCC2)N1[C@@H](C#N)CC[C@H]1C#N.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for DPPI 1c hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	31.28	100
	water	15.64	50

制备储备液 for DPPI 1c hydrochloride

以下数据基于产品分子量 312.8。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.2 mL	15.98 mL	31.97 mL
5 mM	0.64 mL	3.2 mL	6.39 mL
10 mM	0.32 mL	1.6 mL	3.2 mL
50 mM	0.06 mL	0.32 mL	0.64 mL

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产品说明书 for DPPI 1c hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for DPPI 1c hydrochloride

参考文献是支持产品生物活性的出版物。

Wright et al (2006) cis-2-5-dicyanopyrrolidine inhibitors of dipeptidyl peptidase IV: synthesis and in vitro, in vivo, and X-ray crystallographic characterization. J.Med.Chem. 49 3068 PMID: 16722626

If you know of a relevant reference for DPPI 1c hydrochloride, please let us know.

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关键词: DPPI 1c hydrochloride, DPPI 1c hydrochloride supplier, Dipeptidyl, peptidase, IV, DPP-IV, inhibitors, inhibits, Peptidase, Proteinases, Proteases, DPPI1c, hydrochloride, 866396-34-1, DPP4, (DPP-IV), 2783, Tocris Bioscience

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