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eCF 309

Cat. No. 5955 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5955 has been discontinued.

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说明： Potent mTOR inhibitor
化学名： 3-(2-Amino-5-benzoxazolyl)-1-(2,2-diethoxyethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
纯度： ≥98% (HPLC)
说明书
引用文献
评论
文献 (2)
通路 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for eCF 309

eCF 309 is a potent mTOR inhibitor (IC50 = 15 nM). Exhibits >60-fold selectivity for mTOR over PI 3-kinases and is inactive against a panel of other kinases. Inhibits growth of ER-positive MCF7 breast cancer cells in vitro (EC50 = 8.5 nM). Cell permeable.

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of eCF 309 is reviewed on the Chemical Probes website.

技术数据 for eCF 309

分子量 383.41
公式 C18H21N7O3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2001571-40-8
PubChem ID 122163152
InChI Key PSICWGWNIOOULV-UHFFFAOYSA-N
Smiles CCOC(OCC)CN1N=C(C2=CC(N=C(N)O3)=C3C=C2)C4=C1N=CN=C4N

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for eCF 309

参考文献是支持产品生物活性的出版物。

Fraser et al (2016) eCF309: a potent, selective and cell-permeable mTOR inhibitor. Med.Chem.Commun. 4 471

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关键词: eCF 309, eCF 309 supplier, eCF309, mTOR, inhibitors, inhibits, potent, anticancer, 5955, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Cancer Metabolism Research Product Guide

Cancer Metabolism Research Product Guide

This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:

Cancer Metabolism Poster

Cancer Metabolism Poster

This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.

Pathways for eCF 309

mTOR Signaling Pathway

mTOR Signaling Pathway

mTOR is a serine/threonine kinase that nucleates at multiprotein complexes mTORC1 and mTORC2. Signaling by these complexes regulates cell growth, proliferation and survival.