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Embelin

Cat. No. 2156 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2156 has been discontinued.

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说明： Inhibitor of X-linked inhibitor of apoptosis (XIAP); cell-permeable and antitumor
化学名： 2,5-Dihydroxy-3-undecyl-2,5-cyclohexadiene-1,4-dione
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (1)
通路 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for Embelin

Embelin is a cell-permeable, non-peptide inhibitor of X-linked inhibitor of apoptosis (XIAP) (IC50 = 4.1 μM in competition binding assay with Smac peptide); binds to the BIR3 domain, preventing XIAP interaction with caspase-9 and Smac. Inhibits cell growth, induces apoptosis and activates caspase-9 in prostate cancer cells (IC50 4 - 6 μM), but has a weaker effect on normal prostate cells (IC50 = 19 - 20 μM). Overcomes the protective effect of XIAP on apoptosis in XIAP-transfected Jurkat cells. Anti-tumor, analgesic and anti-inflammatory in vivo.

技术数据 for Embelin

分子量 294.39
公式 C17H26O4
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 550-24-3
PubChem ID 3218
InChI Key IRSFLDGTOHBADP-UHFFFAOYSA-N
Smiles OC=1C(=O)C(CCCCCCCCCCC)=C(C(=O)C1)O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Embelin

参考文献是支持产品生物活性的出版物。

Chitra et al (1994) Antitumor, anti-inflammatory and analgesic property of embelin, a plant product. Chemotherapy 40 109 PMID: 7510605

Nikolovska-Coleska et al (2004) Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database. J.Med.Chem. 47 2430 PMID: 15115387

Modak et al (2013) Probing p300/CBP associated factor (PCAF)-dependent pathways with a small molecule inhibitor. ACS Chem.Biol. 8 1311 PMID: 23570531

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关键词: Embelin, Embelin supplier, inhibitors, inhibits, X-linked, apoptosis, XIAP, cell-permeable, antitumor, c-IAP, Inhibitor, of, Apoptosis, (IAP), 2156, Tocris Bioscience

1 篇 Embelin 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Embelin 的部分引用包括：

Barbelanne et al (2013) Pathogenic NPHP5 mutations impair protein interaction with Cep290, a prerequisite for ciliogenesis. Hum Mol Genet 22 2482 PMID: 23446637

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该领域的文献

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Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for Embelin

Apoptosis Signaling Pathway

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.