Emricasan

Cat. No. 7310 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent pan-caspase inhibitor

化学名： N-[2-(1,1-Dimethylethyl)phenyl]-2-oxoglycyl-N-[(1S)-1-(carboxymethyl)-2-oxo-3-(2,3,5,6-tetrafluorophenoxy)propyl]-L-alaninamide

纯度： ≥98% (HPLC)

文献 (5)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Emricasan

Emricasan is a potent caspase inhibitor (IC₅₀ values are 0.3, 0.4, 2, 4, 6, 6 and 20 nM for caspase-9, -1, -3, -6, -7, -8, and -2, respectively). Emricasan is antiapoptotic by inhibiting caspase 8. It also preserves cell viability after infection with several strains of Zika. Emricasan promotes survival of pluripotent stem cells in culture when used in combination with Chroman-1 (Cat. No. 7163), trans-ISRIB (Cat. No. 5284) and Polyamine Supplement x1000 (lyophilized) (Cat. No. 7739), a combination known as CEPT. When used as part of the CEPT cocktail, Emricasan improves survival of differentiated cells following cryopreservation. The compound also reduces hepatic inflammation in an animal model of liver injury. Orally bioavailable.

化合物库 for Emricasan

Emricasan is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Emricasan

分子量	569.51
公式	C₂₆H₂₇F₄N₃O₇
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	254750-02-2
PubChem ID	12000240
InChI Key	SCVHJVCATBPIHN-SJCJKPOMSA-N
Smiles	N(C(C(N[C@H](C(N[C@H](C(COC1=C(F)C(F)=CC(F)=C1F)=O)CC(O)=O)=O)C)=O)=O)C2=C(C(C)(C)C)C=CC=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Emricasan

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	56.95	100
	ethanol	28.48	50

制备储备液 for Emricasan

以下数据基于产品分子量 569.51。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.76 mL	8.78 mL	17.56 mL
5 mM	0.35 mL	1.76 mL	3.51 mL
10 mM	0.18 mL	0.88 mL	1.76 mL
50 mM	0.04 mL	0.18 mL	0.35 mL

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产品说明书 for Emricasan

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Emricasan

参考文献是支持产品生物活性的出版物。

Chen et al (2021) A versatile polypharmacology platform promotes cytoprotection and viability of human pluripotent and differentiated cells. Nat.Methods 18 528 PMID: 33941937

Canbay et al (2004) The caspase inhibitor IDN-6556 attenuates hepatic injury and fibrosis in the bile duct ligated mouse. J.Pharmacol.Exp.Ther. 308 1191 PMID: 14617689

If you know of a relevant reference for Emricasan, please let us know.

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关键词: Emricasan, Emricasan supplier, IDN6556, caspases, inhibitors, pluripotent, potent, stem, cells, CEPT, cocktail, cryopreservation, differentiation, differentiated, zika, maintenance, self-renewal, orally, bioavailable, Antiapoptotic, Caspases, Stem, Cell, Proliferation, Cocktail, 7310, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

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