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Submit ReviewEpirubicin hydrochloride
说明： Inhibits DNA synthesis and function. Inhibits DNA topoisomerase II
别名： 4'-Epidoxorubicin
化学名： (8S,10S)-10-[(3-Amino-2,3,6-trideoxy-α-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,12-naphthacenedione hydrochloride
纯度： ≥96% (HPLC)
生物活性 for Epirubicin hydrochloride
Epirubicin hydrochloride is an antibiotic antitumor agent. Inhibits the synthesis and function of DNA (IC50 = 62.7 μM in rat glioblastoma cell lines) and inhibits the relaxing property of topoisomerase II.
技术数据 for Epirubicin hydrochloride
| 分子量 | 579.98 |
| 公式 | C27H29NO11.HCl |
| 储存 | Desiccate at +4°C |
| 纯度 | ≥96% (HPLC) |
| CAS Number | 56390-09-1 |
| PubChem ID | 32874 |
| InChI Key | MWWSFMDVAYGXBV-FGBJBKNOSA-N |
| Smiles | O=C(C2=C1C(OC)=CC=C2)C3=C(C(O)=C([C@](OC5CC(N)C(O)C(C)O5)([H])C[C@@]([C@@](CO)=O)(O)C4)C4=C3O)C1=O.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Epirubicin hydrochloride
参考文献 for Epirubicin hydrochloride
参考文献是支持产品生物活性的出版物。
Cersosimo et al (1986) Epirubicin: a review of pharmacology, clinical activity, and adverse effects of an adriamycin analogue. J.Clin.Oncol. 4 425 PMID: 3005521
Spadari et al (1986) DNA polymerases and DNA topoisomerases as targets for the development of anticancer drugs. Anticancer Res. 6 935 PMID: 3026237
Schott and Robert (1989) Comparative activity of anthracycline 13-dihydrometabolites against rat glioblastoma cells in culture. Biochem.Pharmacol. 38 4069 PMID: 2597184
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2 篇 Epirubicin hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Epirubicin hydrochloride 的部分引用包括：
Kim and Bynoe (2016) A2A adenosine receptor modulates drug efflux transporter P-glycoprotein at the blood-brain barrier. J Clin Invest 126 1717 PMID: 27043281
Robinson et al (2013) RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs. PLoS One 8 e78641 PMID: 24265703
Epirubicin hydrochloride 的评论
平均评分: 5 (基于 2 条评论。)
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Highly stable.
By
Anonymous on 05/09/2020
分析类型： In Vivo
种属： Mouse
细胞系/组织： brain
10 mg/kg of epirubicin
Epirubicin effectively kills melanoma cells in vitro.
By
Anonymous on 02/14/2019
分析类型： In Vitro
种属： Human
Epirubicin was used at a 20 uM concentration for in vitro culture with SK-MEL-28 and cell viability was monitored over time with live imaging. Arrow indicates when compound was added to media.
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets
Huntington's Disease Research Product Guide
This product guide provides a background to Huntington's disease research and lists around 100 products for the study of:
- Somatic Instability
- Proteolysis and Inclusion Bodies
- Transcriptional Dysregulation
- Mitochondrial Dysfunction
- Nuclear-Cytoplasmic Transport Interference
- Excitotoxicity
- Stem Cells